{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:51Z","timestamp":1740124431564,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Kaposi's sarcoma (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>) persists today as a highly prevalent vascular cancer, often found in HIV patients. Studies have shown that angiopoietin 2 (Ang2), a pro\u2010angiogenic protein, is involved in the pathogenesis of this tumor. However, expression of this protein has not been investigated in oral <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> lesions. Thus, we aimed to investigate the expression of Ang2 in samples of oral <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry was used to evaluate Ang2 expression in 14 oral <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> cases, with degrees of expression being analyzed in a semi\u2010quantitative manner. In addition, clinical information such as age, gender, race, tumor location, size, color, and appearance, as well as <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status, was collected and included in the analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients were white males, mostly <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive, with a mean age of 40\u00a0years. Clinically, the lesions were dark red\/blue\/purple masses, ranging from 1 to 2.5\u00a0cm in diameter, found in various locations such as the tongue, palate, and gingiva. Expression of Ang2 was noted in 72% (10\/14) of the samples. Of these, 10% showed weak expression, 60% moderate, and 30% strong expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that Ang2 is expressed in oral <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> and, consistent with results from previous studies, show that Ang2 may contribute to the pathogenesis of this lesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12574","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T18:30:01Z","timestamp":1490812201000},"page":"1011-1014","source":"Crossref","is-referenced-by-count":3,"title":["Angiopoietin\u20102 is expressed in oral Kaposi's sarcoma"],"prefix":"10.1111","volume":"46","author":[{"given":"Antonio","family":"Rossi","sequence":"first","affiliation":[{"name":"College of Dental Medicine \u2010 Illinois Midwestern University Downers Grove IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Pathology and Medicine Arthur A. Dugoni School of Dentistry University of the Pacific San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cuevas\u2010Nunez","sequence":"additional","affiliation":[{"name":"College of Dental Medicine \u2010 Illinois Midwestern University Downers Grove IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Wright","sequence":"additional","affiliation":[{"name":"TAMU Baylor College of Dentistry Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo M. B.","family":"De\u2010Paula","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Montes Claros Montes Claros Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Basile","sequence":"additional","affiliation":[{"name":"University of Maryland Dental School Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-0174","authenticated-orcid":false,"given":"Bruno C.","family":"Jham","sequence":"additional","affiliation":[{"name":"College of Dental Medicine \u2010 Illinois Midwestern University Downers Grove IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05758.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385032-4.00003-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00217-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3321"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03303-12"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65088-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1515"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-07-0072"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-009-0017-3"},{"key":"e_1_2_7_12_1","first-page":"2145","article-title":"Angiopoietin\u20102 is related to tumor angiogenesis in gastric carcinoma: possible in\u00a0vivo regulation via induction of proteases","volume":"61","author":"Etoh T","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.030"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.02.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2888"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22524"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1384"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02089-06"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.2.649"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:43:27Z","timestamp":1696023807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,8]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jop.12574"],"URL":"https:\/\/doi.org\/10.1111\/jop.12574","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"type":"print","value":"0904-2512"},{"type":"electronic","value":"1600-0714"}],"subject":[],"published":{"date-parts":[[2017,9,8]]}}}