{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:25:33Z","timestamp":1782498333504,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:00:00Z","timestamp":1494028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Oral submucous fibrosis (<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>) is a potentially malignant condition associated with areca nut chewing. Formerly confined to the Indian subcontinent, it is now often seen in Asian populations of the United Kingdom, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> and other developed countries, and is therefore a serious problem for global health. What makes it more sinister is the malignant transformation rate, which has been reported to be around 7.6% over a 17\u2010year period. In this concise article, we review the current trends in the pathophysiology of malignant transformation of <jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jop.12582","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T10:02:45Z","timestamp":1491732165000},"page":"413-417","source":"Crossref","is-referenced-by-count":64,"title":["Oral submucous fibrosis: An update on pathophysiology of malignant transformation"],"prefix":"10.1111","volume":"46","author":[{"given":"Gururaj","family":"Arakeri","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Navodaya Dental College and Hospital Raichur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekar Gowda","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology HCG Cancer Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsalam S.","family":"Aljabab","sequence":"additional","affiliation":[{"name":"Department of Dentistry Faculty of Dentistry King Fahad Medical City King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Chou","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Wan\u2010Fang Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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