{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:41:08Z","timestamp":1768524068418,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is a reported relation between hyperhomocysteinemia and lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>). An increase in homocysteine (Hcy) and the risk of cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) in patients with methylenetetrahydrofolate reductase (<jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content>) mutation has been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To detect <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> (C677T) gene polymorphism, and to find its association with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> risk, Hcy and folic acid levels in patients with <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This hospital\u2010based case\u2010control study included 110 patients with <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>: 70 with cutaneous <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content>) and 40 with oral <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>). A total of 120 age\u2010 and sex\u2010matched healthy subjects were used as controls. Three millilitre venous blood sample was taken for detection of <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> gene polymorphism by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> technique and for measurement of the lipid profile. Hcy and folic acid were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Hypertension was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significantly higher prevalence of hypertension with higher Hcy, triglycerides and cholesterol levels and lower folic acid and <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> levels among patients\u2019 groups. Hypertension with higher Hcy and cholesterol levels together with lower folic acid and <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> levels have been found in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> when compared to <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content>. Patients showed a significant higher percentage of the <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> 677 <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> genotype (<jats:italic>P<\/jats:italic>=.003) and of the <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> 677 T allele (<jats:italic>P<\/jats:italic>=.042) compared to controls. Moreover, there was a higher prevalence of <jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> 677 T allele in patients with <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MTHFR<\/jats:styled-content> 677 gene polymorphism may be a risk factor for the development of the <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, and to predispose these patients to higher risk of <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12588","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T15:02:10Z","timestamp":1493737330000},"page":"1023-1029","source":"Crossref","is-referenced-by-count":12,"title":["Studying the association between methylenetetrahydrofolate reductase (<scp>MTHFR<\/scp>) 677 gene polymorphism, cardiovascular risk and lichen planus"],"prefix":"10.1111","volume":"46","author":[{"given":"Laila","family":"Rashed","sequence":"first","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0796","authenticated-orcid":false,"given":"Rania","family":"Abdel Hay","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"AlKaffas","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen","family":"Ali","sequence":"additional","affiliation":[{"name":"Oral Medicine and Periodontology Department Faculty of Oral and Dental Medicine Cairo University Cairo Egypt"},{"name":"Oral Medicine and Periodontology Department Faculty of Oral and Dental Medicine Misr International University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Kadry","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"CD001168","article-title":"Interventions for treating oral lichen planus","volume":"7","author":"Thongprasom K","year":"2011","journal-title":"Cochrane Database Syst 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