{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:21:36Z","timestamp":1758892896463,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T00:00:00Z","timestamp":1495756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/05062\u20101"],"award-info":[{"award-number":["2012\/05062\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection\u2010induced alterations in the oral mucosa by comparing inflammation, cell maturation, and cytomorphometric changes in oral mucosal cells between <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients undergoing highly active antiretroviral therapy (<jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients undergoing <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content> and 30 non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients were studied. Four smears were obtained from the lateral border of the tongue and floor of the mouth with a cytobrush. One sample was stained by the Papanicolaou technique, and three samples were processed for Feulgen staining. Papanicolaou\u2010stained smears were analyzed by light microscopy, and the cytoplasmic (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>) and nuclear (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>) area were measured with the Software AxioVision 4.7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Wilcoxon signed\u2010rank test showed a significant difference in intermediate epithelial cell types between the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected and non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected groups (<jats:italic>P<\/jats:italic>=.005). However, this difference was not observed for superficial epithelial cell types with (<jats:italic>P<\/jats:italic>=.672) and without a nucleus (<jats:italic>P<\/jats:italic>=.069). Comparative analysis revealed no significant difference in <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.604), <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content> (<jats:italic>P<\/jats:italic>=.298) or NA\/CA (<jats:italic>P<\/jats:italic>=.456) between the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected and non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected groups. Keratohyalin granules were more frequent in the non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected group (<jats:italic>P<\/jats:italic>=.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results showed alterations in cell maturation in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients undergoing <jats:styled-content style=\"fixed-case\">HAART<\/jats:styled-content> with undetectable viral load, but no morphometric changes were observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12590","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T07:12:41Z","timestamp":1494054761000},"page":"840-845","source":"Crossref","is-referenced-by-count":1,"title":["Cytological and cytomorphometric evaluation of the oral mucosa in HIV\u2010infected patients undergoing antiretroviral 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