{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:30:39Z","timestamp":1782275439426,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T00:00:00Z","timestamp":1497139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV15\u201029336A"],"award-info":[{"award-number":["AZV15\u201029336A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin\u20101 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101) and interleukin\u20106 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 cytokine family, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 or its receptor and <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> in the Czech population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 248 subjects, 184 healthy controls, and 64 patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> were genotyped for <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101A<\/jats:italic>\u2010889C&gt;T, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101B<\/jats:italic>\u2010511C&gt;T, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101B<\/jats:italic>+3953C&gt;T, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content><\/jats:italic>86\u00a0bp variable number of tandem repeats (<jats:styled-content style=\"fixed-case\">VNTR<\/jats:styled-content>s) in intron 2, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic>\u2010597G&gt;A, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic>\u2010572G&gt;C, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic>\u2010174G&gt;C, and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106R<\/jats:italic>+48992A&gt;C by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences between investigated polymorphisms in healthy subjects and patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> were detected (<jats:italic>P<\/jats:italic>&gt;.05). In addition, complex analysis also revealed similar <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> haplotype frequencies between both groups (<jats:italic>P<\/jats:italic>&gt;.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> or <jats:italic>its receptor<\/jats:italic> gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12594","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:52:32Z","timestamp":1495576352000},"page":"1030-1035","source":"Crossref","is-referenced-by-count":13,"title":["Association study of <i>interleukin\u20101<\/i> family, <i>interleukin\u20106,<\/i> and <i>its receptor<\/i> gene polymorphisms in patients with recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-8929","authenticated-orcid":false,"given":"Lydie","family":"Izakovicova Holla","sequence":"first","affiliation":[{"name":"Clinic of Stomatology Institution Shared with St. Anne's Faculty Hospital Faculty of Medicine Masaryk University Brno Czech Republic"},{"name":"Department of Pathophysiology Faculty of Medicine Masaryk University Brno Czech 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