{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:36:51Z","timestamp":1790800611746,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371154"],"award-info":[{"award-number":["81371154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271137"],"award-info":[{"award-number":["81271137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>Oral lichen planus (OLP<\/jats:styled-content>) is a T\u2010cell\u2010mediated chronic inflammatory oral mucosal disease of unknown etiology, and liquefaction degeneration in the basal keratinocytes is one of the specific histological changes. However, the understanding of liquefaction degeneration is still very limited, and how does it affect the prognosis of LP<\/jats:styled-content> is largely unknown. Therefore, the objective of this study was to clarify the intrinsic change behind the liquefaction degeneration in lichen planus and to evaluate the effect of the OLP<\/jats:styled-content>\u2010typical cytokine, IFN<\/jats:styled-content>\u2010\u03b3, on these changes.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Biopsies were collected from patients with OLP<\/jats:styled-content>; immunochemistry staining was performed to analyze E\u2010cadherin, vimentin, CK<\/jats:styled-content>19, \u03b21 integrin, nestin, STAT<\/jats:styled-content>1, and STAT<\/jats:styled-content>3 expression. Primary oral epithelial cells were cultured in vitro, and 20 ng\/mL IFN<\/jats:styled-content>\u2010\u03b3 was applied to assay the effect on epithelial cells.<\/jats:p><\/jats:sec>Results<\/jats:title>E\u2010cadherin expression was decreased but vimentin expression was increased in the OLP<\/jats:styled-content> epithelial cells that undergo liquefaction degeneration, showing the typical epithelial\u2010mesenchymal transition (EMT<\/jats:styled-content>) alteration. In vitro research showed that the OLP<\/jats:styled-content>\u2010typical cytokine, IFN<\/jats:styled-content>\u2010\u03b3, possesses EMT<\/jats:styled-content>\u2010inducing ability, and the primary oral epithelial cells stimulated by IFN<\/jats:styled-content>\u2010\u03b3 acquired some properties of cancer stem cells, expressing more \u03b21 integrin, \u03b16 integrin, and nestin. In addition, the major downstream mediator of IFN<\/jats:styled-content>\u2010\u03b3 receptor, STAT<\/jats:styled-content>1, was expressed more intensive and extensive with the malignant transition of OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Liquefaction degeneration in oral lichen planus is an EMT<\/jats:styled-content> phenomenon, the IFN<\/jats:styled-content>\u2010\u03b3 may be the main inducer, and IFN<\/jats:styled-content>\u2010\u03b3 signaling might be implicated in malignant transition of OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12595","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T13:32:46Z","timestamp":1496064766000},"page":"1015-1022","source":"Crossref","is-referenced-by-count":22,"title":["The cellular character of liquefaction degeneration in oral lichen planus and the role of interferon 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