{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:01:04Z","timestamp":1791554464200,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007059","name":"Northwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007059","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>It is unclear why human papillomavirus (HPV<\/jats:styled-content>)\u2010related head and neck squamous cell carcinoma (HNSCC<\/jats:styled-content>) has improved clinical behavior compared to HPV<\/jats:styled-content>\u2010negative HNSCC<\/jats:styled-content>. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD<\/jats:styled-content>3 and CD<\/jats:styled-content>8 TIL<\/jats:styled-content> pattern in HPV<\/jats:styled-content>\u2010positive and HPV<\/jats:styled-content>\u2010negative tumors.<\/jats:p><\/jats:sec>Methods<\/jats:title>Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n=21 HPV DNA<\/jats:styled-content>\u2010positive, n=19 HPV DNA<\/jats:styled-content>\u2010negative). CD<\/jats:styled-content>3 and CD<\/jats:styled-content>8 T\u2010cell immunostaining were performed on whole\u2010slide sections to quantify tumor\u2010infiltrating lymphocyte (TIL<\/jats:styled-content>) density and assess its morphology.<\/jats:p><\/jats:sec>Results<\/jats:title>A subset of cases (HPV<\/jats:styled-content>\u2010positive) displayed a unique TIL<\/jats:styled-content> pattern consisting of circumferential peritumoral population T cells, which was absent in the HPV<\/jats:styled-content>\u2010negative cases. The presence of peritumoral cuffing was strongly predictive of improved recurrence\u2010free survival compared to cases that lacked this morphologic pattern of immune infiltrate. Four HPV<\/jats:styled-content>\u2010positive cases lacked the pattern, including two cases with disease recurrence.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>For the first time, we show an architectural pattern of immune infiltrate in HNSCC<\/jats:styled-content> is seen exclusively in HPV<\/jats:styled-content>\u2010positive patients with improved recurrence\u2010free survival and suggests an organized host immunological response contributes to disease control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12605","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T18:26:46Z","timestamp":1497983206000},"page":"972-978","source":"Crossref","is-referenced-by-count":16,"title":["Peritumoral cuffing by T\u2010cell tumor\u2010infiltrating lymphocytes distinguishes HPV<\/scp>\u2010related oropharyngeal squamous cell carcinoma from oral cavity squamous cell carcinoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-2144","authenticated-orcid":false,"given":"Kate","family":"Poropatich","sequence":"first","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Feinberg Medical School Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Fontanarosa","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Feinberg Medical School Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshonna","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Feinberg Medical School Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Woloschak","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Feinberg Medical School Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Paintal","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirtee","family":"Raparia","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine Chicago Chicago IL USA"},{"name":"Robert H Lurie Comprehensive Cancer Center Department of Medicine\u2010Division of Hematology\/Oncology Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Feinberg Medical School Northwestern University Chicago IL USA"},{"name":"Robert H Lurie Comprehensive Cancer Center Department of Medicine\u2010Division of Hematology\/Oncology Northwestern University Feinberg School of Medicine Chicago IL 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