{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:40:50Z","timestamp":1778647250437,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral potentially malignant disorders harbour variable and unpredictable risk for squamous carcinoma development. Whilst current management strategies utilise histopathological diagnoses, dysplasia grading and targeted intervention for \u201chigh\u2010risk\u201d lesions, clinicians are unable to predict malignant potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Detailed, retrospective clinico\u2010pathological analysis of potentially malignant lesions undergoing malignant transformation, from a 590 patient cohort treated by interventional laser surgery and followed for a mean of 7.3 years, was undertaken. Clinical outcome was documented at study census date (31 December 2014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 99 patients (16.8%) developed cancer: 71 (12%) seen \u201cunexpectedly\u201d upon excision and 28 (4.8%) progressing to malignancy at a median of 87.3 months post\u2010surgery. Thirty \u201cunexpected\u201d excisions were micro\u2010invasive (42.3%) arising primarily in severely dysplastic precursors (75%) at ventro\u2010lateral tongue and floor of mouth sites (54.5%); 1 patient (1.4%) had a cancer\u2010related death, whilst 58 (81.7%) were disease free. A total of 19 of 28 \u201cprogressive\u201d cancers (67.9%) arose at new sites, with erythroleukoplakia a significant predictor of malignancy (<jats:italic>P<\/jats:italic> = .0019). Nine (32.1%) developed at the same precursor site, with 6 (77.7%) on the ventro\u2010lateral tongue and floor of mouth. Three (10.7%) were micro\u2010invasive, 9 patients (32.1%) died from metastatic disease and 12 (42.9%) were disease free (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Squamous carcinoma may arise at the site of a precursor lesion as transformation or new\u2010site development via field cancerisation. Whilst interventional surgery facilitates early diagnosis and treatment of occult disease, thus reducing risk from same\u2010site transformation, new\u2010site cancer is a significant long\u2010term risk for patients with potentially malignant disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12625","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T10:12:37Z","timestamp":1503223957000},"page":"888-895","source":"Crossref","is-referenced-by-count":33,"title":["Profiling cancer risk in oral potentially malignant disorders\u2014A patient cohort study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-7975","authenticated-orcid":false,"given":"P. J.","family":"Thomson","sequence":"first","affiliation":[{"name":"Oral &amp; Maxillofacial Surgery School of Dentistry Oral Health Centre University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Goodson","sequence":"additional","affiliation":[{"name":"Oral &amp; Maxillofacial Surgery School of Dentistry Oral Health Centre University of Queensland Brisbane QLD Australia"},{"name":"Newcastle University Medicine Malaysia Iskandar Puteri Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Newcastle University Medicine Malaysia Iskandar Puteri Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118702840.ch3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.04.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0189"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/809248"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.11.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12065"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)80007-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.70104.x"},{"key":"e_1_2_8_12_1","first-page":"1683","article-title":"Intervention efficacy and malignant transformation to oral cancer among patients with leukoplakia","volume":"10","author":"Shiu MN","year":"2003","journal-title":"Oncol Rep"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00491.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-007-0014-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01054.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2013.03.014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.06.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12339"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00782.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2015.02.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2015.08.268"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01740.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2000.0012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.12.014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.1999.0130"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12625","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:44:39Z","timestamp":1696023879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jop.12625"],"URL":"https:\/\/doi.org\/10.1111\/jop.12625","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}