{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:34:50Z","timestamp":1773848090665,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral potentially malignant disorders (PMD) harbour unpredictable risk for squamous cell carcinoma development. Current management requires tissue biopsy for histopathology characterisation, dysplasia grading and targeted intervention to \u201chigh\u2010risk\u201d lesions, although evidence\u2010based guidelines are limited and diagnoses subjective. This study investigated the use of adjunctive oral brush biopsy techniques during the management of PMD in a <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> hospital population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of a 310 <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content> patient cohort presenting to Maxillofacial Surgery in Newcastle upon Tyne with new, single\u2010site lesions between December 2009 and May 2014. Patients underwent Orcellex<jats:sup>\u00ae<\/jats:sup> brush biopsy and liquid\u2010based cytology examination in addition to conventional biopsy techniques, with management proceeding along established care pathways. Patient demographics, cytology data, most significant histopathology diagnoses and clinical outcome were all documented at the study census date (31.12.15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 170 male &amp; 140 female patients (age range 18\u201091\u00a0years), exhibiting primarily leukoplakia (86.5%) at floor of mouth and ventrolateral tongue sites (44.9%), were identified. Management comprised: observation (49.7%), laser surgery (44.9%), antifungal treatment (3.5%) and Head &amp; Neck clinic referral following cancer diagnosis (1.9%). Clinical outcomes were as follows: disease free (51.3%), persistent <jats:styled-content style=\"fixed-case\">PMD<\/jats:styled-content> (42.3%) and malignant transformation (6.4%). Histology and cytology diagnoses strongly correlated (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.305). Treatment modality, lesion site, histology and cytology diagnoses were the best predictors of clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Orcellex<jats:sup>\u00ae<\/jats:sup> brush cytology provides reliable diagnoses consistent with conventional histopathology and offers less invasive, adjunctive assessment appropriate for long\u2010term monitoring of patients in specialist clinics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12627","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T08:36:36Z","timestamp":1503304596000},"page":"896-901","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of oral brush biopsy in potentially malignant disorder management"],"prefix":"10.1111","volume":"46","author":[{"given":"M. L.","family":"Goodson","sequence":"first","affiliation":[{"name":"Oral &amp; Maxillofacial Surgery Oral Health Centre School of Dentistry University of Queensland Brisbane QLD Australia"},{"name":"Newcastle University Medicine Malaysia Johor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Newcastle University Medicine Malaysia Johor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-7975","authenticated-orcid":false,"given":"P. J.","family":"Thomson","sequence":"additional","affiliation":[{"name":"Oral &amp; Maxillofacial Surgery Oral Health Centre School of Dentistry University of Queensland Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118702840.ch3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2001.0189"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/809248"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.11.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2013.24"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.07.489"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.11.024"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.03.254"},{"key":"e_1_2_8_12_1","first-page":"224","article-title":"Orcellex\u00ae brush biopsy and liquid\u2010based cytology \u2013 assessment of a new diagnostic technique in oral potentially malignant disorder management","volume":"117","author":"Goodson ML","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21581"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-39"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.10.022"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.102482"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095389"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2008.01.003"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:44:41Z","timestamp":1696023881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jop.12627"],"URL":"https:\/\/doi.org\/10.1111\/jop.12627","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}