{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:11:23Z","timestamp":1773771083122,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune\u2010mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response\u2010related genes in the different clinical forms of oral lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed to analyse the <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation patterns in three distinct groups of oral lichen planus: (i) reticular\/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> extraction from biopsies, the samples were submitted to digestions by methylation\u2010sensitive and methylation\u2010dependent enzymes and double digestion. The relative percentage of methylated <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> for each gene was provided using real\u2010time polymerase chain reaction arrays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hypermethylation of the <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>5A<\/jats:italic> gene was observed only in the control group (59.0%). A higher hypermethylation of the <jats:italic><jats:styled-content style=\"fixed-case\">ELANE<\/jats:styled-content><\/jats:italic> gene was found in reticular\/plaque lesions (72.1%) compared to the erosive lesions (50.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show variations in the methylation profile of immune response\u2010related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12645","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T10:13:54Z","timestamp":1507112034000},"page":"91-95","source":"Crossref","is-referenced-by-count":11,"title":["DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus"],"prefix":"10.1111","volume":"47","author":[{"given":"Aline Fernanda","family":"Cruz","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Gon\u00e7alves","family":"de Resende","sequence":"additional","affiliation":[{"name":"Stomatology Service of Hospital Odilon Behrens Belo Horizonte 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