{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:40:56Z","timestamp":1792636856969,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T00:00:00Z","timestamp":1509148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Osteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab\u2010related osteonecrosis of the jaw (<jats:styled-content style=\"fixed-case\">DRONJ<\/jats:styled-content>) at the Cancer Institute of Lorraine (<jats:styled-content style=\"fixed-case\">ICL<\/jats:styled-content>) and to highlight necrosis risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the <jats:styled-content style=\"fixed-case\">ICL<\/jats:styled-content> during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded. The <jats:italic>P<\/jats:italic>\u2010value was set at .005.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 141 patients treated at the <jats:styled-content style=\"fixed-case\">ICL<\/jats:styled-content> between January 2010 and December 2015 were included. All patients were treated with XGEVA<jats:sup>\u00ae<\/jats:sup>. Of the 141 patients included in the study, 10 developed <jats:styled-content style=\"fixed-case\">DRONJ<\/jats:styled-content>. The incidence of <jats:styled-content style=\"fixed-case\">DRONJ<\/jats:styled-content> increases with the duration of follow\u2010up as follows: 3% at 1 year, 7% at 2 years, and 8% from 30 months on. No risk factor for necrosis could be identified except the realization of prior dental extraction (<jats:italic>P<\/jats:italic> = .025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results raise important questions about the dental management of these patients, in particular, concerning the healing period between dental extractions and the initiation of Denosumab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12646","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T19:22:35Z","timestamp":1507144955000},"page":"66-70","source":"Crossref","is-referenced-by-count":30,"title":["Denosumab\u2010related osteonecrosis of the jaw: A retrospective study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-481X","authenticated-orcid":false,"given":"Claire","family":"Egloff\u2010Juras","sequence":"first","affiliation":[{"name":"Department of Head and Neck and Dental Surgery Institut de Canc\u00e9rologie de Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Dental Faculty of Nancy Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Gallois","sequence":"additional","affiliation":[{"name":"Department of Head and Neck and Dental Surgery Institut de Canc\u00e9rologie de Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Dental Faculty of Nancy Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Salleron","sequence":"additional","affiliation":[{"name":"Cellule Data\u2010biostatistiques Institut de Canc\u00e9rologie de Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Massard","sequence":"additional","affiliation":[{"name":"Department of Oncology Institut de Canc\u00e9rologie de Lorraine 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