{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:29:14Z","timestamp":1777004954401,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010174","name":"University of Colorado","doi-asserted-by":"publisher","award":["NCI\u2010CCSG P30CA046934"],"award-info":[{"award-number":["NCI\u2010CCSG P30CA046934"]}],"id":[{"id":"10.13039\/100010174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Glandular odontogenic cyst (<jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>) demonstrates a significant predilection toward localized biologic aggressiveness and recurrence. <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content> shares certain histopathologic features with intraosseous mucoepidermoid carcinoma (<jats:styled-content style=\"fixed-case\">IMEC<\/jats:styled-content>). The current investigation evaluates a group of recurrent, biologically aggressive <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s to determine whether any cases demonstrated unique histologic features or mastermind\u2010like2 (<jats:italic><jats:styled-content style=\"fixed-case\">MAML<\/jats:styled-content>2<\/jats:italic>) rearrangements common to <jats:styled-content style=\"fixed-case\">IMEC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Microscopic slides from 11 previously diagnosed <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s were stained with hematoxylin and eosin and assessed by 2 study participants for 10 classic histopathologic features required to establish a diagnosis of <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>. Cases were evaluated utilizing break\u2010apart fluorescent in situ hybridization (<jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>) analysis for the presence of <jats:italic><jats:styled-content style=\"fixed-case\">MAML<\/jats:styled-content>2<\/jats:italic> gene rearrangements. Clinical and demographic data on all patients were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age for patients included in the study was 55.27 years with a range of 36 to 72 years. The most common presenting symptom was a jaw expansion, and all cysts presented initially as a unilocular or multilocular radiolucency. Cysts displayed a minimum of 6 of 10 histologic parameters necessary for a diagnosis of <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>. One case demonstrated <jats:italic><jats:styled-content style=\"fixed-case\">MAML<\/jats:styled-content>2<\/jats:italic> rearrangements by <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content>. That case also showed marked ciliation of cyst\u2010lining epithelial cells and extensive mucous\u2010secreting goblet cell proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings in the current study are in concert with previous investigations, and although this study finds only limited molecular evidence to support the premise that recurrent biologically aggressive <jats:styled-content style=\"fixed-case\">GOC<\/jats:styled-content>s are a precursor to <jats:styled-content style=\"fixed-case\">IMEC<\/jats:styled-content>, detection of <jats:italic><jats:styled-content style=\"fixed-case\">MAML<\/jats:styled-content>2<\/jats:italic> rearrangements in 1 case suggests that such a theoretic transition, while rare, is possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12658","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T17:13:07Z","timestamp":1511802787000},"page":"192-197","source":"Crossref","is-referenced-by-count":22,"title":["Assessment of biologically aggressive, recurrent glandular odontogenic cysts for mastermind\u2010like 2 (<i><scp>MAML<\/scp>2<\/i>) rearrangements: histopathologic and fluorescent in situ hybridization (<scp>FISH<\/scp>) findings in 11 cases"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-7676","authenticated-orcid":false,"given":"Robert O.","family":"Greer","sequence":"first","affiliation":[{"name":"Division of Oral and Maxillofacial Pathology School of Dental Medicine Anschutz Medical Campus University of Colorado Aurora CO USA"},{"name":"Department of Pathology School of Medicine Anschutz Medical Campus University of Colorado Aurora CO USA"},{"name":"Division of Medical Oncology and University of Colorado Cancer Center Anschutz Medical Campus University of Colorado Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Eskendri","sequence":"additional","affiliation":[{"name":"Section of Oral and Maxillofacial Pathology New York Presbyterian\/Queens Flushing NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Freedman","sequence":"additional","affiliation":[{"name":"Section of Oral and Maxillofacial Pathology New York Presbyterian\/Queens Flushing NY USA"},{"name":"Oral Pathology Laboratory Inc. Flushing NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moni","family":"Ahmadian","sequence":"additional","affiliation":[{"name":"Section of Oral and Maxillofacial Pathology New York Presbyterian\/Queens Flushing NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Murakami\u2010Walter","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and University of Colorado Cancer Center Anschutz Medical Campus University of Colorado Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marileila","family":"Varella\u2010Garcia","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and University of Colorado Cancer Center Anschutz Medical Campus University of Colorado Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0534-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874210601408010001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20110162"},{"key":"e_1_2_8_5_1","first-page":"86","article-title":"Intraosseous mucoepidermoid carcinoma: report of two cases","volume":"15","author":"Atarbashi Moghadam S","year":"2014","journal-title":"J Dent (Shiraz)"},{"key":"e_1_2_8_6_1","first-page":"163","volume-title":"WHO Classification of Head and Neck Tumours","author":"Brandwein\u2010Gensier M","year":"2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.01.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12195"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181de3021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0298-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01428.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.180"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00259"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12526"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.oraloncology.2003.11.007","article-title":"Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst","volume":"40","author":"Pires FR","year":"2014","journal-title":"Oral Oncol"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T09:43:50Z","timestamp":1695721430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jop.12658"],"URL":"https:\/\/doi.org\/10.1111\/jop.12658","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]}}}