{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:15:05Z","timestamp":1768086905113,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,3]],"date-time":"2017-12-03T00:00:00Z","timestamp":1512259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011970","name":"International Team for Implantology","doi-asserted-by":"crossref","award":["973-2014"],"award-info":[{"award-number":["973-2014"]}],"id":[{"id":"10.13039\/501100011970","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Objective<\/jats:title>This study was intended to investigate the effects of icariin on the healing of tooth extraction sites under the systemic administration of zoledronic and dexamethasone.<\/jats:p><\/jats:sec>Method<\/jats:title>Thirty female rats underwent bilateral ovariectomy and were randomly assigned to 5 groups: SS<\/jats:styled-content> group received a weekly injection of saline, while ZD<\/jats:styled-content>, ZD<\/jats:styled-content> + LICA<\/jats:styled-content>, ZD<\/jats:styled-content> + MICA<\/jats:styled-content>, and ZD<\/jats:styled-content> + HICA<\/jats:styled-content> groups received zoledronic with dexamethasone for 8 weeks. One week later, mandibular first molars were extracted in all groups. Then, 30, 60, and 120 mg\/kg icariin were intragastrically given to ZD<\/jats:styled-content> + LICA<\/jats:styled-content>, ZD<\/jats:styled-content> + MICA<\/jats:styled-content>, and ZD<\/jats:styled-content> + HICA<\/jats:styled-content> groups daily for 10 weeks, while saline was given to SS<\/jats:styled-content> group and ZD<\/jats:styled-content> group. Blood samples and mandibles were harvested for examinations after 10 weeks.<\/jats:p><\/jats:sec>Results<\/jats:title>Significantly smaller wound area was noted in SS<\/jats:styled-content> and ZD<\/jats:styled-content> + HICA<\/jats:styled-content> groups, but the incidence of bisphosphonate\u2010related osteonecrosis of the jaws (BRONJ<\/jats:styled-content>) was not significantly different. Groups injected with zoledronic and dexamethasone had higher C\u2010terminal cross\u2010linked telopeptide of type 1 collagen (CTX<\/jats:styled-content>\u20101), tartrate\u2010resistant acid phosphatase 5b (TRACP<\/jats:styled-content> 5b), and the number of osteoclast cells, with less vascular endothelial growth factor (VEGF<\/jats:styled-content>) and osteocalcin (OCN<\/jats:styled-content>). In contrast, CTX<\/jats:styled-content>\u20101, TRACP<\/jats:styled-content> 5b, and the number of osteoclast cells declined after using icariin and promoted VEGF<\/jats:styled-content> and OCN<\/jats:styled-content> were noted and the effects were in a dosage\u2010dependent manner.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Concurrent use of zoledronic and dexamethasone inhibits the expression of VEGF<\/jats:styled-content>, OCN<\/jats:styled-content>, and wound healing and increases the number of osteoclast cells, serum CTX<\/jats:styled-content>\u20101, and TRACP<\/jats:styled-content>\u20105b after discontinuation for 10 weeks. Icariin weakens those effects in a dose\u2010dependent manner but does not influence the onset of BRONJ<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12659","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:21:22Z","timestamp":1512469282000},"page":"198-205","source":"Crossref","is-referenced-by-count":12,"title":["The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-1516","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu 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