{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:27:12Z","timestamp":1772828832796,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010syndromic orofacial cleft (<jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>) is a common craniofacial deformity among newborns. The <jats:styled-content style=\"fixed-case\">GREM<\/jats:styled-content>1 gene is correlated with orofacial development. The aim of our study was to investigate the association between a single\u2010nucleotide polymorphism in the <jats:styled-content style=\"fixed-case\">GREM<\/jats:styled-content>1 gene and this malformation in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>aPshot mini\u2010sequencing technique was used to genotype the locus rs1258763 of the <jats:styled-content style=\"fixed-case\">GREM<\/jats:styled-content>1 gene in 331 patients with <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> and 271 individuals in a control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For <jats:styled-content style=\"fixed-case\">GREM<\/jats:styled-content>1 rs1258763, there was a significant difference between the <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> case group and control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.022). Children carrying <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotypes had an increased risk of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.62, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.15\u20102.30; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.52, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.09\u20102.12). In the cleft subgroup, we found that the <jats:styled-content style=\"fixed-case\">GREM<\/jats:styled-content>1 rs1258763 <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> genotype might contribute to the elevated risk of the cleft lip with or without cleft palate (<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>\/P) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.029). Non\u2010significant differences were found between the cleft palate only (<jats:styled-content style=\"fixed-case\">CPO<\/jats:styled-content>) and control groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.077).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings revealed that the <jats:styled-content style=\"fixed-case\">GREM<\/jats:styled-content>1 polymorphism was significantly associated with the risk of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in the Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12662","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T14:16:35Z","timestamp":1510928195000},"page":"206-210","source":"Crossref","is-referenced-by-count":7,"title":["Association between a single\u2010nucleotide polymorphism in the GREM1 gene and non\u2010syndromic orofacial cleft in the Chinese population"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-7734","authenticated-orcid":false,"given":"Xiaotong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongquan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanru","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Stomatology Plastic surgery hospital Chinese Academy of Medical Science and Peking Union Medical College Shijingshan District Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The Fourth Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery The First Affiliated Hospital Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Stomatology Tumor Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9503.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14364"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.580"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2933"},{"key":"e_1_2_7_6_1","first-page":"782821","article-title":"Genetics and management of the patient with orofacial cleft","volume":"2012","author":"Brito LA","year":"2012","journal-title":"Plast Surg 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