{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:57:19Z","timestamp":1782766639139,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000674","name":"Physiological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009082","name":"Universidad Cat\u00f3lica de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009082","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Burning mouth syndrome (<jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>) is a neuropathic orofacial pain condition of unknown aetiology that encompasses intra\u2010oral burning pain without abnormal clinical findings. Psychological, neural and inflammatory processes are associated with <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> pathogenesis. Currently, studies characterising plasma cytokine\/chemokine profiles with pain and depression in patients with <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> are lacking. Considering that inflammation is associated with the pathophysiology of <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>, and that inflammation is closely associated with pain and depression, we aimed to correlate depressive symptomatology and oral cavity pain with plasma cytokine\/chemokine signatures in a cohort of patients with <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, plasma protein levels of Th1 cytokines (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012p70, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1), Th2 cytokines (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013) and the chemokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 were assessed in patients with <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> (n = 10) and healthy volunteers (n = 10), using pro\u2010inflammatory\u201010\u2010plex assays. Clinical histories, alongside self\u2010rated oral cavity pain intensities and depressive symptomatology were assessed using a visual analogue scale and the 16\u2010item Quick Inventory of Depressive Symptomatology questionnaires, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present evidence that <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> is associated with increased depressive symptomatology and enhanced oral cavity pain. Plasma isolated from BMS patients display enhanced expression of the pro\u2010inflammatory chemokine <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, when compared to plasma from healthy individuals. Plasma <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 signature correlates with pain and depressive symptomatology in the study cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, these findings indicate that plasma <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 profiles are dysregulated in <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> and that modulation of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108 production in the disorder may be a tool in the management of <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> symptomatology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12666","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T07:09:20Z","timestamp":1512112160000},"page":"158-165","source":"Crossref","is-referenced-by-count":44,"title":["Plasma <scp>IL<\/scp>\u20108 signature correlates with pain and depressive symptomatology in patients with burning mouth syndrome: Results from a pilot study"],"prefix":"10.1111","volume":"47","author":[{"given":"Alison","family":"Barry","sequence":"first","affiliation":[{"name":"Department of Physiology University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken D.","family":"O'Halloran","sequence":"additional","affiliation":[{"name":"Department of Physiology University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Cork University Dental School and Hospital University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"McCreary","sequence":"additional","affiliation":[{"name":"Cork University Dental School and Hospital University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6012-2291","authenticated-orcid":false,"given":"Eric J.","family":"Downer","sequence":"additional","affiliation":[{"name":"Discipline of Physiology School of Medicine Trinity Biomedical Sciences Institute Trinity College Dublin University of Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-013-0336-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90336-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02052.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00275-6"},{"key":"e_1_2_7_6_1","first-page":"59","article-title":"Psychosocial profiles of patients with burning mouth 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