{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:49:04Z","timestamp":1770223744362,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aimed at underlying the molecular regulatory mechanism and overall biological functions of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 in tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression level of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 was examined by <jats:styled-content style=\"fixed-case\">QRT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. In particular, Tca\u20108113 cell line was selected for subsequent experiments, in which the expression level of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 was the most significant. Meanwhile, the effects of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 on cells proliferation, cell cycle distribution, and invasion of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cells were explored using <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> knockdown tools with <jats:styled-content style=\"fixed-case\">CCK<\/jats:styled-content>\u20108, flow cytometry analysis, colony formation, and transwell assay. Further, bioinformatic analysis and the dual\u2010luciferase reporter assay both were conducted to invalidate the ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s regulatory mechanism of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 was obviously upregulated in <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> tissues and cell lines. Moreover, it was found that <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 served as a competing endogenous <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) through sponging miR\u2010765 and ultimately modulated the derepression of laminin subunit gamma 2 (<jats:styled-content style=\"fixed-case\">LAMC<\/jats:styled-content>2). The inhibitory effects of miR\u2010765 on <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> cells proliferation, invasion as well as cell cycle distribution can be restored by the ectopic overexpression of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511. Additionally, the restored capacity of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 promoted the expression of <jats:styled-content style=\"fixed-case\">LAMC<\/jats:styled-content>2, which was a downstream target of miR\u2010765 and can be negatively regulated by miR\u2010765.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A novel molecular axis of <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511\/miR\u2010765\/<jats:styled-content style=\"fixed-case\">LAMC<\/jats:styled-content>2 was investigated to regulate the tumor development of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LINC<\/jats:styled-content>00511 promoted the expression of <jats:styled-content style=\"fixed-case\">LAMC<\/jats:styled-content>2 via the ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> mechanism of sponging miR\u2010765. The ce<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> regulatory network provided a novel understanding of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> pathogenesis and also shed light on exploiting the new field of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010directed therapy against <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12677","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T13:13:48Z","timestamp":1515590028000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["<scp>LINC<\/scp>00511 interacts with miR\u2010765 and modulates tongue squamous cell carcinoma progression by targeting <scp>LAMC<\/scp>2"],"prefix":"10.1111","volume":"47","author":[{"given":"Junhai","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Stomatology Affiliated Hospital of Ji'ning Medical University Ji'ning Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shandong Energy Zibo Mining Group Co. Ltd Central Hospital Zibo Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-7537","authenticated-orcid":false,"given":"Sen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Suining Central Hospital Suining Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.186805"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.04.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.2992"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5445"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14200"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11528"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2735-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2016.94"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317705849"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12485"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.228"},{"key":"e_1_2_10_13_1","first-page":"30393","article-title":"Long non\u2010coding RNAs in thyroid cancer: biological functions and clinical significance","volume":"17","author":"Sui F","year":"2017","journal-title":"Mol Cell Endocrinol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3575"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479205"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5806"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-2634"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317707882"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216677353"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3716"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.09.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M112.023507"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.607"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T05:41:27Z","timestamp":1695015687000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/jop.12677"],"URL":"https:\/\/doi.org\/10.1111\/jop.12677","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"2018-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}