{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:26:11Z","timestamp":1783052771854,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to systematically review the efficacy of photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) in the management of symptomatic oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>PubMed\/<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Scopus, and <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content> Web of knowledge were searched until July 2017, using the following keywords: OLP, erosive lichen planus, lichen planus, and PDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five clinical studies were included. The risk of bias was considered high in 4 studies and moderate in 1 study. The efficacy of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was compared with topical corticosteroids in all included studies. Laser wavelengths, duration of irradiation, and power density ranged between 420\u2010660 nm, 30 seconds to 10 minutes, and 10\u2010500 <jats:styled-content style=\"fixed-case\">mW<\/jats:styled-content>\/cm<jats:sup>2<\/jats:sup>, respectively. All studies reported <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> to be effective in the management of symptomatic <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. Two studies reported <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> to be as effective as corticosteroids, 1 study reported a better efficacy of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> compared to corticosteroids, whereas 2 studies found <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> to be inferior to corticosteroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The limited available evidence suggests that <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is an effective treatment option for the management of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. However, due to the limited number of studies included in this review and heterogeneity among these studies, more well\u2010designed clinical trials with adequate sample sizes are highly warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12684","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T13:50:11Z","timestamp":1516369811000},"page":"326-332","source":"Crossref","is-referenced-by-count":27,"title":["Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-1377","authenticated-orcid":false,"given":"Sadeq Ali","family":"Al\u2010Maweri","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences AlFarabi Colleges Riyadh Saudi Arabia"},{"name":"Department of Oral Medicine Faculty of Dentistry Sana'a University Sana'a 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