{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:45Z","timestamp":1787015685335,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400517"],"award-info":[{"award-number":["81400517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study was to investigate association and potentially destructive role of Th9\/IL\u20109 and their synergistic interaction with Th17 cells in elevating MMP9 production in local lesions of oral lichen planus (OLP) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Oral mucosal tissues were obtained from OLP patients and healthy controls (HC) and then divided into an epithelial part (EP) or a lamina propria part (LP). Both EP and LP subsets were assessed for IL\u20109 and MMP9 mRNA levels by real\u2010time quantitative PCR (qPCR). Flow cytometry was used to detect the CD4+ T helper subset Th9 (IL\u20109\n                      <jats:sup>+<\/jats:sup>\n                      IL\u201017\n                      <jats:sup>\u2212<\/jats:sup>\n                      CD4\n                      <jats:sup>+<\/jats:sup>\n                      ) and Th17 (IL\u20109\n                      <jats:sup>\u2212<\/jats:sup>\n                      IL\u201017\n                      <jats:sup>+<\/jats:sup>\n                      CD4\n                      <jats:sup>+<\/jats:sup>\n                      ) in co\u2010cultured CD4+ Th cells and oral keratinocytes of OLP. IL\u20109, IL\u201017, and MMP9 in co\u2010culture supernatant were detected by ELISA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The qPCR results demonstrated that IL\u20109 and MMP9 mRNA levels were positively correlated in OLP lesions, and both significantly elevated in EP and LP lesions of erosive type OLP. Th9 and Th17 cells were significantly elevated in co\u2010cultures of CD4+ Th cells and keratinocytes, and MMP9, IL\u20109, and IL\u201017 levels were simultaneously increased. In vitro\n                      <jats:italic>,<\/jats:italic>\n                      recombinant human IL\u201017 treatment significantly enhanced MMP9 protein and mRNA levels, while a synergistic effect of IL\u20109 and IL\u201017 was not observed. However, further results showed Th17 cells, IL\u201017, and MMP9 were increased significantly when recombinant IL\u20109 was added to the cultured CD4+ T cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated that Th9\/IL\u20109 can induce elevated levels of MMP9 to aggravate OLP disease severity, which may occur directly through increasing Th17 levels or indirectly through a synergistic role with Th17.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.12690","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T10:52:37Z","timestamp":1518000757000},"page":"425-433","source":"Crossref","is-referenced-by-count":23,"title":["The association and potentially destructive role of Th9\/IL\u20109 is synergistic with Th17 cells by elevating MMP9 production in local lesions of oral lichen planus"],"prefix":"10.1111","volume":"47","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Capital Medical University Beijing China"},{"name":"State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-9558","authenticated-orcid":false,"given":"Xiaobing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Periodontics School of Stomatology Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Stomatology Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300405"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.10"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00077.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0814-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12028"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt039"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2920"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2016.1166214"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev252"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00456.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2011.635804"},{"key":"e_1_2_7_13_1","first-page":"39","article-title":"CD4+CD25+ T regulatory cells and MMP\u20109 as diagnostic salivary biomarkers in oral lichen planus","volume":"20","author":"Fathi MS","year":"2013","journal-title":"Egypt J Immunol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1846-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.10.012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.01.015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-392589"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.10.004"},{"key":"e_1_2_7_19_1","first-page":"147","article-title":"Periodontal conditions in patients with oral lichen planus: a pilot study","volume":"43","author":"Lopez\u2010Jornet P","year":"2012","journal-title":"Quintessence Int"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9594-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1131-z"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102698"},{"key":"e_1_2_7_23_1","first-page":"99","article-title":"Expression of TGF\u2010beta receptors in CD8+ T cells of oral lichen planus","volume":"43","author":"Lei L","year":"2008","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20869"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12633.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12405"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12550"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:35:14Z","timestamp":1695540914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,6]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/jop.12690"],"URL":"https:\/\/doi.org\/10.1111\/jop.12690","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,6]]}}}