{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:29:38Z","timestamp":1771464578996,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The grading of oral epithelial dysplasia (<jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>) is not applicable to oral submucous fibrosis (<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>) cases due to the presence of atrophic epithelium. The mucosal margins associated with resected <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> specimens are often closely related to transformed cells. In this study, we compared the histomorphological alterations (dysplastic features) in the atrophic epithelium of <jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> patients with the mucosal margins of <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 17 dysplastic features in 37 patients with <jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> (biopsy site: buccal mucosa) and 37 patients with <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> (mucosal margins involving buccal mucosa) using histopathological staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dysplastic features, such as keratin pearls within rete ridges, nuclear pleomorphism, and atypical mitotic figures, were not observed in the epithelium of the <jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> groups. Basal cell hyperplasia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.016), abnormal superficial mitosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.010), increased nuclear\u2010cytoplasmic ratio (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.034), and hyperchromasia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.031) were predominantly seen in the <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content> group. We found no statistically significant differences in the following parameters: irregular epithelial stratification (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.00), loss of basal cell polarity (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.237), presence of drop\u2010shaped rete ridges (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.077), increased number of mitotic figures (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.154), premature keratinization in single cells (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.499), anisonucleosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.289), anisocytosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.079), cellular pleomorphism (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.317), and increased number and size of nucleoli (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.129).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased basal cell layer hyperplasia, abnormal superficial mitosis, increased nuclear\u2010cytoplasmic ratio, and hyperchromasia are high\u2010risk features for <jats:styled-content style=\"fixed-case\">OSMF<\/jats:styled-content>, and affected patients should be followed on a priority basis for the early detection of <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12699","type":"journal-article","created":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T11:16:37Z","timestamp":1519557397000},"page":"410-416","source":"Crossref","is-referenced-by-count":27,"title":["Dysplastic features relevant to malignant transformation in atrophic epithelium of oral submucous fibrosis: A preliminary study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-0957","authenticated-orcid":false,"given":"Sachin C.","family":"Sarode","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Dr. D. Y. Patil Dental College and Hospital Dr. D.Y. Patil Vidyapeeth Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minal","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology &amp; Microbiology Sharad Pawar Dental College &amp; Hospital Datta Meghe Institute of Medical Sciences Wardha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-7694","authenticated-orcid":false,"given":"Amol","family":"Gadbail","sequence":"additional","affiliation":[{"name":"Department of Dentistry Indira Gandhi Government Medical College Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2288-5167","authenticated-orcid":false,"given":"Satyajit","family":"Tekade","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology &amp; Microbiology Modern Dental College &amp; Research Centre Indore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankargouda","family":"Patil","sequence":"additional","affiliation":[{"name":"Division of Oral Pathology Department of Maxillofacial Surgery and Diagnostic Sciences College of Dentistry Jazan University Jazan Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gargi S.","family":"Sarode","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Dr. D. Y. Patil Dental College and Hospital Dr. D.Y. Patil Vidyapeeth Pune India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"177","article-title":"Tumours of the oral cavity and oropharynx","volume":"67","author":"Branes L","year":"2005","journal-title":"Pathol Genet"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.04.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.11.005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-14-99"},{"key":"e_1_2_6_6_1","first-page":"ZD31","article-title":"Malignant conversion of oral submucous fibrosis in surgically treated case","volume":"8","author":"Arora R","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.08.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.10.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01209.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(66)90367-7"},{"key":"e_1_2_6_11_1","first-page":"224","article-title":"Oral submucous fibrosis as a precancerous condition","volume":"92","author":"Pindborg JJ","year":"1984","journal-title":"Scand J Dent Res"},{"key":"e_1_2_6_12_1","first-page":"112","volume-title":"WHO Classification of Tumours of the Head and Neck","author":"Rebel J","year":"2017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12553"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00115-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12612"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.178746"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2013.01.004"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80377-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275948"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891x.2004.014030.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016481003782041"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-253"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00849.x"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:35:25Z","timestamp":1695555325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/jop.12699"],"URL":"https:\/\/doi.org\/10.1111\/jop.12699","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,12]]}}}