{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:06:42Z","timestamp":1790492802877,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Humans may be exposed to pesticides such as fungicides, herbicides, and insecticides, during occupational and non\u2010occupational activities. Pesticides could be related to cancer development mainly because of their effects on the endocrine and immune systems and their cumulative effect. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of head and neck cancer (<jats:styled-content style=\"fixed-case\">HNC<\/jats:styled-content>). A literature search for cohort studies was conducted in the PubMed, Web of science, and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (<jats:styled-content style=\"fixed-case\">SIGN<\/jats:styled-content>) checklist. One thousand one hundred and thirty\u2010two studies were identified. Thirty\u2010two were included. Most of the studies found addressed occupational exposure to pesticides and were conducted in Europe and North America. Eleven high\u2010quality studies were found. Most of them found no association between exposure to pesticides and increased risk of <jats:styled-content style=\"fixed-case\">HNC<\/jats:styled-content>. Two studies found some evidence of a positive association between pesticide (malathion and atrazine) exposure and thyroid cancer. The literature review does not support a clear evidence for association between pesticides exposure and <jats:styled-content style=\"fixed-case\">HNC<\/jats:styled-content>. Only limited evidence points to a positive association between exposure to some pesticides and thyroid cancer. Further standardized studies based on appropriate designs are required to clarify the effect of pesticides on the genesis of <jats:styled-content style=\"fixed-case\">HNC<\/jats:styled-content>, considering dose, length of exposure, and type of pesticide.<\/jats:p>","DOI":"10.1111\/jop.12701","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T13:42:39Z","timestamp":1519825359000},"page":"641-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pesticides as risk factors for head and neck cancer: A review"],"prefix":"10.1111","volume":"47","author":[{"given":"Veruska Lima Moura","family":"Brasil","sequence":"first","affiliation":[{"name":"Oral Pathology Section Department of Clinical and Preventive Dentistry School of Dentistry Universidade Federal de Pernambuco Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Bitu","family":"Ramos Pinto","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Clinical and Preventive Dentistry School of Dentistry Universidade Federal de Pernambuco Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Ferreti","family":"Bonan","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Clinical and Preventive Dentistry School of Dentistry Universidade Federal de Pernambuco Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Otorhinolaryngology A. C. Camargo Cancer Center S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-4645","authenticated-orcid":false,"given":"Danyel Elias","family":"da Cruz Perez","sequence":"additional","affiliation":[{"name":"Oral Pathology Section Department of Clinical and Preventive Dentistry School of Dentistry Universidade Federal de Pernambuco Recife Pernambuco Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph8051402"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1788-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40199-015-0090-0"},{"key":"e_1_2_7_5_1","first-page":"1712","article-title":"Non\u2010cancer health effects of pesticides: systematic review and implications for family doctors","volume":"53","author":"Sanborn M","year":"2007","journal-title":"Can Fam Physician"},{"key":"e_1_2_7_6_1","first-page":"1704","article-title":"Cancer health effects of pesticides","volume":"53","author":"Bassil KL","year":"2007","journal-title":"Can Fam Physician"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5791"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2015.1020182"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00081-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30513-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70134-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000398801"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101929"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000036169.90864.e2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.855"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23286"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01694759"},{"key":"e_1_2_7_18_1","first-page":"809","article-title":"Risk of cancer in pesticide applicators in Swedish agriculture","volume":"46","author":"Wiklund K","year":"1989","journal-title":"Br J Ind Med"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-199502000-00008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2113"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009543"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106683"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.017038"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91898-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009069"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqr067"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052936"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2017.06.003"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.997"},{"issue":"1","key":"e_1_2_7_30_1","first-page":"39","article-title":"Cancer incidence in the Agricultural Health Study","volume":"31","author":"Alavanja MCR","year":"2005","journal-title":"Scand J Work Environ Health"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1103561"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24020"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21758"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh264"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-017-0298-1"},{"key":"e_1_2_7_36_1","first-page":"234","article-title":"A cohort mortality study of forestry workers exposed to phenoxy acid herbicides","volume":"48","author":"Green LM","year":"1991","journal-title":"Br J Ind Med"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039890209602089"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102798"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29621"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181f72b7c"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2003.010934"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2011.02.064"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003379"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.2013.46.6.309"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28961"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0269-7491(99)00110-4"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00273"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0491"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1993.1032"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2432"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:41:18Z","timestamp":1695004878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,24]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/jop.12701"],"URL":"https:\/\/doi.org\/10.1111\/jop.12701","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,24]]},"assertion":[{"value":"2018-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}