{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:08:34Z","timestamp":1787987314511,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Pozna\u0144 University of Medical Sciences","doi-asserted-by":"crossref","award":["502-14-02209325-09854"],"award-info":[{"award-number":["502-14-02209325-09854"]}],"id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent aphthous stomatitis is a common ulcerative disorder of the oral mucosa, where the immune impairment may develop in genetically predisposed subjects exposed to certain environmental factors. The aim of the study was to investigate the frequency of anaemia, iron and vitamin B12 deficiency in recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) and to explore its impact on the clinical presentation of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 141 adults including the following: 71 subjects with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> and 70 controls were enrolled in the study. A detailed dental and haematological assessment, including full blood count, serum iron and vitamin B12 evaluation, was performed in all study participants. The results were statistically analysed with Mann\u2010Whitney, Kruskal\u2010Wallis, <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> and Fisher tests with <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 designated as a significance level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recurrent aphthous stomatitis patients were found to suffer anaemia, iron and vitamin B12 deficiency more frequently than the controls. The mean serum iron levels were also significantly lower in <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> subjects than in controls, although still within the norm. The lowest mean serum iron levels were observed in patients with a mild course of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. No significant differences in mean serum iron and vitamin B12 levels were revealed as a function of stratification according to the number of lesions per single flare\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of our study indicate an association between iron and vitamin B12 deficiency and <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> in a Polish population. However, as the haematinic deficiencies did not significantly modify the course and clinical phenotype of the disease, further studies to explore their role in <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> aetiology are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12703","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T17:48:35Z","timestamp":1520012915000},"page":"531-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Haematinic deficiencies and patient clinical profiles in Polish patients with recurrent aphthous stomatitis (<scp>RAS<\/scp>)"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-3964","authenticated-orcid":false,"given":"Zuzanna","family":"\u015alebioda","sequence":"first","affiliation":[{"name":"Department of Oral Mucosa Diseases University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Krawiecka","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosa Diseases University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Szponar","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosa Diseases University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Dorocka\u2010Bobkowska","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosa Diseases University of Medical Sciences Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"74","article-title":"Guideline for the diagnosis and treatment of recurrent aphthous stomatitis for dental practitioners","volume":"7","author":"Tarakji B","year":"2015","journal-title":"J Int Oral Health"},{"key":"e_1_2_7_3_1","first-page":"213","article-title":"Aphthous ulcers as a multifactorial problem","volume":"52","author":"Ujevi\u0107 A","year":"2013","journal-title":"Acta Clin Croat"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90470-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12045"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51401"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.12.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01243.x"},{"key":"e_1_2_7_9_1","first-page":"590","article-title":"Niedokrwisto\u015b\u0107 z niedoboru \u017celaza","volume":"12","author":"Orlicz\u2010Szcz\u0119sna G","year":"2011","journal-title":"Curr Probl Psychiatry"},{"key":"e_1_2_7_10_1","first-page":"123","article-title":"Wp\u0142yw wybranych sk\u0142adnik\u00f3w od\u017cywczych po\u017cywienia na funkcjonowanie uk\u0142adu odporno\u015bciowego. 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