{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:06:27Z","timestamp":1771027587420,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences (TUMS)","award":["132\/595"],"award-info":[{"award-number":["132\/595"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Induction of podoplanin by transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) has been shown in a number of lesions but not in odontogenic tumors (OTs). We evaluated the association between these markers in OTs for the first time and compared their expression among the different neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunohistochemistry using monoclonal antibody against podoplanin and TGF\u2010\u03b2 was performed on 76 odontogenic cysts and tumors. Spearman's correlation coefficient, Kruskal\u2010Wallis, and Mann\u2010Whitney <jats:italic>U<\/jats:italic> tests followed by adjustment with Bonferroni were used for statistical analysis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant difference in podoplanin expression was found among the lesions consisting of solid ameloblastomas, adenomatoid odontogenic tumors, ameloblastic fibromas, odontogenic myxomas (OMs), odontogenic keratocysts, and calcifying odontogenic cysts. Significant differences were observed only between OMs and each of the other neoplasms. Podoplanin immunostaining in the connective tissue was absent in most lesions. TGF\u2010\u03b2 was significantly different among the study sample but not between the lesions in paired comparisons. None of the studied OTs showed significant correlations between podoplanin\u2010TGF\u2010\u03b2, in either the epithelium or the stroma. These markers were also descriptively reported in calcifying epithelial odontogenic tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The inductive effect of TGF\u2010\u03b2 on podoplanin seems to be limited, if any, in odontogenic lesions. Podoplanin appears to play a role in some aspects of OTs with epithelial or mixed origins. Despite the possible participation of podoplanin in tumorigenesis, it may not necessarily be involved in the aggressive behavior of OTs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12710","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T07:36:40Z","timestamp":1522049800000},"page":"519-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is podoplanin expression associated with transforming growth factor\u2010\u03b2 signaling in odontogenic cysts and tumors?"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-9493","authenticated-orcid":false,"given":"Shahroo","family":"Etemad\u2010Moghadam","sequence":"first","affiliation":[{"name":"Dental Research Center Dentistry Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-7992","authenticated-orcid":false,"given":"Mojgan","family":"Alaeddini","sequence":"additional","affiliation":[{"name":"Dental Research Center Dentistry Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0588-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00818.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2015.2451"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000184"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2012.06.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.11.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01924.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3445"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2006.06.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.12.028"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.06.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12475"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-016-0149-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.00121.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12016"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.12.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00851.x"},{"key":"e_1_2_8_19_1","first-page":"3103","article-title":"Expression of the insulin\u2010like growth factor\u20101 receptor in odontogenic myxoma","volume":"36","author":"Friedrich RE","year":"2016","journal-title":"Anticancer Res"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3353\/omp.8.125"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.01.048"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12494"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022061"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12221"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-011-0261-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.54.241"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1503"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2016.11.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0114-OA.1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12203"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12524"}],"container-title":["Journal of Oral Pathology &amp; 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