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However, the signaling pathways that trigger apoptosis are still unknown. The aim of this study was to investigate the expression of endoplasmic reticulum (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>) stress\u2010related proteins in the condylar cartilage of rabbits following <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty healthy adult rabbits were randomly assigned to the experimental and sham\u2010operated control groups (n\u00a0=\u00a012). The experimental rabbits were subjected to surgical <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content> in the right temporomandibular joints. The production of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress\u2010related proteins <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EBP<\/jats:styled-content> homologous protein (<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>), glucose\u2010regulated protein 78 (<jats:styled-content style=\"fixed-case\">GRP<\/jats:styled-content>78), cleaved caspase\u20103, and caspase\u201012 in cartilage was evaluated by immunohistochemistry, quantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, and Western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that the expression of <jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GRP<\/jats:styled-content>78, cleaved caspase\u20103, and caspase\u201012 increased significantly along with degenerative changes in cartilage after <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> stress pathway is activated in <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content> cartilage and might promote the development of <jats:styled-content style=\"fixed-case\">TMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12715","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:34:54Z","timestamp":1523939694000},"page":"606-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Expression of endoplasmic reticulum stress protein in rabbit condyle cartilage following anterior disk displacement"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-6916","authenticated-orcid":false,"given":"Ting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Stomatology First Affiliated Hospital Zhejiang University Hangzhou Zhejiang China"},{"name":"School of Stomatology Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Chinese Medical University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Center First Affiliated Hospital Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Stomatology First Affiliated Hospital Zhejiang University Hangzhou Zhejiang China"},{"name":"School of Stomatology Zhejiang University Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology First Affiliated Hospital Zhejiang University Hangzhou Zhejiang China"},{"name":"School of Stomatology Zhejiang University Hangzhou Zhejiang 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