{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:37:43Z","timestamp":1790969863782,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T00:00:00Z","timestamp":1524960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Background<\/jats:title>Clinically identifiable potentially malignant disorders (PMD<\/jats:styled-content>) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL<\/jats:styled-content>) and proliferative verrucous leukoplakia (PVL<\/jats:styled-content>) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective review of 590 PMD<\/jats:styled-content> patients treated in Northern England by CO2<\/jats:sub> laser surgery between 1996 and 2014 was carried out. Lesions exhibiting lichenoid or proliferative verrucous features were identified from the patient database and their clinicopathological features and outcome post\u2010treatment determined at the study census date of 31 December 2014.<\/jats:p><\/jats:sec>Results<\/jats:title>One hundred and 98 patients were identified as follows: 118 OLL<\/jats:styled-content> and 80 PVL<\/jats:styled-content>, most frequently leukoplakia at ventrolateral tongue and floor of mouth sites, equally distributed between males and females. Most exhibited dysplasia on incision biopsy (72% OLL<\/jats:styled-content>; 85% PVL<\/jats:styled-content>) and were treated by laser excision rather than ablation (88.1% OLL<\/jats:styled-content>; 86.25% PVL<\/jats:styled-content>). OLL<\/jats:styled-content> were more common in younger patients (OLL<\/jats:styled-content> 57.1\u00a0year; PVL<\/jats:styled-content> 62.25\u00a0years; P<\/jats:italic>\u00a0=\u00a0.008) and more likely than PVL<\/jats:styled-content> to present as erythroleukoplakia (OLL<\/jats:styled-content> 15.3%; PVL<\/jats:styled-content> 2.5%; P<\/jats:italic>\u00a0=\u00a0.003). Whilst no significant difference was seen between OLL<\/jats:styled-content> and PVL<\/jats:styled-content> achieving disease\u2010free status (69.5% and 65%, respectively; P<\/jats:italic>\u00a0=\u00a0.55), this was less than the overall PMD<\/jats:styled-content> cohort (74.2%). MT<\/jats:styled-content> was identified in 2 OLL<\/jats:styled-content> (1.7%) and 2 PVL<\/jats:styled-content> (2.5%) during follow\u2010up.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>One\u2010third of PMD<\/jats:styled-content> cases showed features of OLL<\/jats:styled-content> or PVL<\/jats:styled-content>, probably representing a disease presentation continuum. Post\u2010treatment disease\u2010free status was less common in OLL<\/jats:styled-content> and PVL<\/jats:styled-content>, although MT<\/jats:styled-content> was infrequent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12716","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:34:00Z","timestamp":1523939640000},"page":"557-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Potentially malignant disorders revisited\u2014The lichenoid lesion\/proliferative verrucous leukoplakia conundrum"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-7975","authenticated-orcid":false,"given":"Peter J.","family":"Thomson","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Oral & Maxillofacial Surgery The University of Hong Kong Hong Kong, SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela L.","family":"Goodson","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Oral & Maxillofacial Surgery The University of Hong Kong Hong Kong, SAR China"},{"name":"Newcastle University Medicine Malaysia Iskandar Puteri Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Newcastle University Medicine Malaysia Iskandar Puteri Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118702840.ch3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.11.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12626"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12625"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2015.08.268"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2017.02.1026"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.147830"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(85)90315-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12641"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.08.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2014.01.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.09.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12036"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2016.12.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e839"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.114887"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2015.08.263"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01632.x"}],"container-title":["Journal of Oral Pathology & Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T12:10:29Z","timestamp":1694952629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,29]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/jop.12716"],"URL":"https:\/\/doi.org\/10.1111\/jop.12716","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,29]]},"assertion":[{"value":"2018-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}