{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:15:43Z","timestamp":1770293743340,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005013","name":"Academic Center for Education, Culture and Research","doi-asserted-by":"publisher","award":["C\u20101395\u2010047"],"award-info":[{"award-number":["C\u20101395\u2010047"]}],"id":[{"id":"10.13039\/501100005013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005013","name":"Academic Center for Education, Culture and Research","doi-asserted-by":"publisher","award":["C\u20101395\u2010048"],"award-info":[{"award-number":["C\u20101395\u2010048"]}],"id":[{"id":"10.13039\/501100005013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In recent decades, anti\u2010angiogenic treatment strategy has been well described in cancer treatment. The anti\u2010angiogenic activity of both bevacizumab and aflibercept has been researched on 10 previously established primary oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>) cells of an Iranian population with different levels of purity, in an attempt to find the most effective anti\u2010angiogenic\u2010targeted drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate and compare the effect of bevacizumab and aflibercept on vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) secretion of 10 primary <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> cells, cell proliferation and viability were assessed by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MTT<\/jats:styled-content> assays. In addition, cell migration was studied using scratch assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> impressively expressed in all primary cancer cells. Although both drugs significantly reduced the secretion of <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>, the effect of aflibercept was more prominent. Also, bevacizumab\u2010treated cells migration was lower than the control group and the cells treated with aflibercept showed the lowest migration rate compared to bevacizumab and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010angiogenic\u2010targeted drugs, especially Af, might be effective in treatment of patients with <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> in combination with conventional surgical treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12717","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T20:05:25Z","timestamp":1524168325000},"page":"575-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Anti\u2010angiogenic efficacy of aflibercept and bevacizumab in primary oral squamous cell carcinoma 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