{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:04:27Z","timestamp":1791896667370,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["1740587"],"award-info":[{"award-number":["1740587"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["131412\/2017\u20105"],"award-info":[{"award-number":["131412\/2017\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406744\/20165"],"award-info":[{"award-number":["406744\/20165"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>Oral potentially malignant disorders (OPMD) are chronic conditions, which have a higher risk of transformation to oral squamous cell carcinoma. The aim of this systematic review and meta\u2010analysis was to answer the question: \u201cWhat is the prevalence of oral potentially malignant disorders among adults?\u201d Studies reporting the prevalence of these conditions (leukoplakia, erythroplakia, oral submucous fibrosis [OSMF], and actinic cheilitis) were selected, only studies in which a clinical assessment and histopathological confirmation were performed were included. Of the 5513 studies, 22 met the inclusion criteria for qualitative and quantitative analyses. The risk of bias (RoB) of the selected studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Seven studies were classified as high risk, 12 as moderate risk, and 3 as low RoB. The meta\u2010analysis showed that the prevalence of OPMD was 4.47% (95% CI = 2.43\u20107.08). The most prevalent OPMDs were OSMF (4.96%; 95% CI = 2.28\u20108.62) and leukoplakia (4.11%; 95% CI = 1.98\u20106.97). OPMDs were identified more commonly in males (59.99%; 95% CI = 41.27\u201077.30). Asian and South American\/Caribbean populations had the highest prevalence rates of 10.54% (95% CI = 4.60\u201018.55) and 3.93% (95% CI = 2.43\u20105.77), respectively. The overall prevalence of OPMD worldwide was 4.47%, and males were more frequently affected by these disorders. The prevalence of OPMD differs between populations; therefore, further population\u2010based studies may contribute to the better understanding of these differences.<\/jats:p>","DOI":"10.1111\/jop.12726","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T14:01:15Z","timestamp":1525788075000},"page":"633-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":386,"title":["Prevalence of oral potentially malignant disorders: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-268X","authenticated-orcid":false,"given":"Fernanda Weber","family":"Mello","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-4809","authenticated-orcid":false,"given":"Andressa Fernanda Paza","family":"Miguel","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-2059","authenticated-orcid":false,"given":"Kamile Leonardi","family":"Dutra","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-9695","authenticated-orcid":false,"given":"Andr\u00e9 Lu\u00eds","family":"Porporatti","sequence":"additional","affiliation":[{"name":"Brazilian Centre for Evidence\u2010based Research Florian\u00f3polis Brazil"},{"name":"Department of Dentistry Health Sciences Center Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-0746","authenticated-orcid":false,"given":"Saman","family":"Warnakulasuriya","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine King's College London London UK"},{"name":"WHO Collaborating Centre for Oral Cancer London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-1550","authenticated-orcid":false,"given":"Eliete Neves Silva","family":"Guerra","sequence":"additional","affiliation":[{"name":"Laboratory of Oral Histopathology School of Health Sciences University of Bras\u00edlia Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-8771","authenticated-orcid":false,"given":"Elena Riet Correa","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Pathology Health Sciences Center Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumors","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.5906"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.02.025"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.866"},{"key":"e_1_2_6_7_1","first-page":"12","article-title":"Smokeless tobacco and oral potentially malignant disorders in South Asia: a systematic review and meta\u2010analysis","volume":"20","author":"Khan Z","year":"2017","journal-title":"Nicotine Tob Res"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.10"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322010000400003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.12.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2017.07.032"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00582.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(03)00102-7"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60903-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.11.001"},{"key":"e_1_2_6_18_1","first-page":"182","volume-title":"Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data","author":"Joanna Briggs Institute","year":"2014"},{"key":"e_1_2_6_19_1","unstructured":"HigginsJ GreenS.Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration 2011."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01712.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.2.519"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2014.40932"},{"key":"e_1_2_6_23_1","unstructured":"SouzaLSD.An\u00e1lise das patologias bucais e maxilofaciais de uma popula\u00e7\u00e3o brasileira durante um per\u00edodo de 15 anos. 2014\/04 2014:34\u201034."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.5935\/1676-2444.20140008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242012000300009"},{"key":"e_1_2_6_26_1","first-page":"261","article-title":"Defini\u00e7\u00e3o do grupo de risco para leucoplasias bucais: estudo retrospectivo entre os anos de 1999 e 2009","volume":"16","author":"Haas Junior O","year":"2011","journal-title":"RFO UPF"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00820.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-009-0196-y"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.01.017"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1676-24442009000300008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0218.58391"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01391.x"},{"key":"e_1_2_6_33_1","first-page":"e448","article-title":"A clinicopathologic study of oral leukoplakia and erythroplakia in a Thai population","volume":"38","author":"Lapthanasupkul P","year":"2007","journal-title":"Quintessence Int"},{"key":"e_1_2_6_34_1","article-title":"Estudio histol\u00f3iico de lesiones de la cavidad bucal en el quinquenio 2001\u20102005","volume":"11","author":"S\u00e1nchez JOB","year":"2007","journal-title":"Arch Med Camaguey"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.00967.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300104.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(99)70115-0"},{"key":"e_1_2_6_38_1","first-page":"41","article-title":"Lesiones precancerosas (leucoplasia y liquen plano oral) en el paciente geri\u00e1trico","volume":"20","author":"Garc\u00eda\u2010Pola Vallejo MJ","year":"1997","journal-title":"Aten Primaria"},{"key":"e_1_2_6_39_1","first-page":"89","article-title":"A comparative study of oral lichen planus and leukoplakia in two Argentine populations","volume":"10","author":"Femopase FL","year":"1997","journal-title":"Acta Odontol Latinoam"},{"key":"e_1_2_6_40_1","first-page":"537","article-title":"Lesiones cancerizables en patolog\u00eda bucal","volume":"75","author":"Cecotti EL","year":"1997","journal-title":"Bol Acad Nac Med B Aires"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1790::AID-CNCR2820380456>3.0.CO;2-I"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<1021::AID-CNCR2820360327>3.0.CO;2-W"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ebd.6401242"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_230_17"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.98970"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.05.001"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01910.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330807"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12570"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.190900"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20347"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T02:41:28Z","timestamp":1695004888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/jop.12726"],"URL":"https:\/\/doi.org\/10.1111\/jop.12726","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,6]]},"assertion":[{"value":"2018-04-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}