{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:23:08Z","timestamp":1790623388471,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:00:00Z","timestamp":1527379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007083","name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004591","name":"Kansainv\u00e4lisen Liikkuvuuden ja Yhteisty\u00f6n Keskus","doi-asserted-by":"publisher","award":["CIMO TM\u201015\u20109588"],"award-info":[{"award-number":["CIMO TM\u201015\u20109588"]}],"id":[{"id":"10.13039\/501100004591","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"Helsingin Yliopisto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,9]]},"abstract":"\n Background<\/jats:title>\n \n Certain periodontopathogenic bacteria have been linked to cancers.\n Treponema denticola<\/jats:italic>\n (\n Td)<\/jats:italic>\n is associated with severe periodontitis. Chymotrypsin\u2010like proteinase (\n CTLP<\/jats:styled-content>\n ), a major virulence factor of\n Td<\/jats:italic>\n , can degrade various host proteins and peptides, and modulate inflammatory responses. However, the role of\n Td<\/jats:italic>\n in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of\n Td<\/jats:italic>\n \u2010\n CTLP<\/jats:styled-content>\n in early\u2010stage mobile tongue squamous cell carcinoma (\n MTSCC<\/jats:styled-content>\n ) and its relation to clinical and pathological characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The immunopositivity of\n Td\u2010<\/jats:italic>\n CTLP<\/jats:styled-content>\n was assessed in samples obtained from 60 patients with\n MTSCC<\/jats:styled-content>\n and associated with their clinicopathological data. Additionally,\n Td<\/jats:italic>\n \u2010\n CTLP<\/jats:styled-content>\n expression was compared with immunoexpression of matrix metalloproteinases (\n MMP<\/jats:styled-content>\n \u20108 and\n MMP<\/jats:styled-content>\n \u20109), toll\u2010like receptors (\n TLR<\/jats:styled-content>\n \u20102,\n TLR<\/jats:styled-content>\n \u20104,\n TLR<\/jats:styled-content>\n \u20107 and\n TLR<\/jats:styled-content>\n \u20109), c\u2010Myc, Ki\u201067, Bmi\u20101 and Snail.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Treponema denticola<\/jats:italic>\n \u2010chymotrypsin\u2010like proteinase was present in 95% of\n MTSCC<\/jats:styled-content>\n tumours of which many (40.4%) showed high immunopositivity.\n Td\u2010<\/jats:italic>\n CTLP<\/jats:styled-content>\n positivity was significantly associated with invasion depth, tumour diameter and the expression of\n TLR<\/jats:styled-content>\n \u20107,\n TLR<\/jats:styled-content>\n \u20109 and c\u2010Myc. High\n Td\u2010<\/jats:italic>\n CTLP<\/jats:styled-content>\n immunopositivity in younger patients (\u2264 60 years old) predicted early relapse.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our data indicate that\n Td<\/jats:italic>\n and its\n CTLP<\/jats:styled-content>\n are present in early\u2010stage\n MTSCC<\/jats:styled-content>\n carcinoma and may contribute to carcinogenesis, and therefore provide novel perspectives into intervention and therapeutic measures of\n MTSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12729","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T17:50:29Z","timestamp":1525974629000},"page":"764-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Treponema denticola<\/i>\n chymotrypsin\u2010like proteinase is present in early\u2010stage mobile tongue squamous cell carcinoma and related to the clinicopathological features"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1629-6884","authenticated-orcid":false,"given":"Dyah","family":"Listyarifah","sequence":"first","affiliation":[{"name":"Department of Medicine Clinicum University of Helsinki, and Helsinki University Central Hospital Helsinki Finland"},{"name":"Department of Dental Biomedical Sciences Faculty of Dentistry Universitas Gadjah Mada Yogyakarta Indonesia"},{"name":"Department of Oral and Maxillofacial Diseases Clinicum, University of Helsinki, and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko T.","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases Clinicum, University of Helsinki, and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"M\u00e4kinen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caj","family":"Haglund","sequence":"additional","affiliation":[{"name":"Department of Surgery Helsinki University Hospital, HUS Helsinki Finland"},{"name":"Research Program Unit Translational Cancer Biology University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grenier","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Dentaire Universit\u00e9 Laval Quebec City QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valtteri","family":"H\u00e4yry","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rehabilitation University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology and Department of Oral Pathology and Medicine Dentistry Unit Faculty of Dentistry Faculty of Health Sciences Universidad Aut\u00f3noma de Chile University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fclay","family":"Yucel\u2010Lindberg","sequence":"additional","affiliation":[{"name":"Division of Periodontology Department of Dental Medicine Karolinska Institutet Huddinge 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