{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:01:36Z","timestamp":1775066496500,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["#LBH\u2010Q14111"],"award-info":[{"award-number":["#LBH\u2010Q14111"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The role of underlying genetic factors in the pathogenesis of nonsyndromic orofacial clefts (<jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>) remains poorly understood. Although genomewide association studies (<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> have successfully identified a large number of novel genetic risk loci, association results of replication studies are inconsistent across different populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) (rs7922405 at 10q26.3, rs73039426 at 19q13.11, rs7552 at 2p24.2, rs1788160 at 8q22.2, rs9381107 at 6p24.3, and rs17095681 at 10q25.3) were analyzed for an association with <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in 1062 participants of Chinese descent (596 patients and 466 controls). We applied the multifactor dimensionality reduction (<jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>) method to detect potential gene\u2010gene (G \u00d7 G) interactions in the six <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype or allele frequencies of <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s rs7922405, rs73039426, and rs7552 showed significant differences between the controls and patients with <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>, whereas no association was shown between three <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (rs1788160, rs17095681, and rs9381107) and <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content> analysis did not reveal significant G \u00d7 G interactions for susceptibility to <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirmed that three genes (rs7922405 of <jats:styled-content style=\"fixed-case\">MGMT<\/jats:styled-content>, rs73039426 of <jats:styled-content style=\"fixed-case\">RHPN<\/jats:styled-content>2, and rs7552 of <jats:styled-content style=\"fixed-case\">FAM<\/jats:styled-content>49A) may contribute to <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content> in Chinese populations. <jats:styled-content style=\"fixed-case\">MGMT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RHPN<\/jats:styled-content>2 are associated with <jats:styled-content style=\"fixed-case\">NSOC<\/jats:styled-content>, which is herein demonstrated for the first time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12758","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T14:45:21Z","timestamp":1530110721000},"page":"796-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic variants of <scp>MGMT<\/scp>,<scp> RHPN<\/scp>2, and <scp>FAM<\/scp>49A contributed to susceptibility of nonsyndromic orofacial clefts in a Chinese population"],"prefix":"10.1111","volume":"47","author":[{"given":"Chunyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinna","family":"Shi","sequence":"additional","affiliation":[{"name":"Scientific Research Management Office The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kewen","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang 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