{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:39Z","timestamp":1787015679050,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Saudi Cultural Office in London"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Sj\u00f6gren's syndrome (\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      ) is an autoimmune inflammatory disease that affects the exocrine glands. The absence of early diagnostic markers contributes to delays in its diagnosis. Identification of changes in the protein profile of saliva is considered one of the promising strategies for the discovery of new biomarkers for\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To identify salivary protein biomarkers with potential for use in discriminating between different lymphoma risk subgroups of\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Parotid and whole mouth saliva samples were collected from patients with\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      , including those in subgroups at higher risk of developing or with confirmed lymphoma, non\u2010\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      sicca disease controls and healthy subjects. An initial proteomics analysis by mass spectrometry (\n                      <jats:styled-content style=\"fixed-case\">LCMSMS<\/jats:styled-content>\n                      ) identified S100A8\/A9 as a biomarker and was followed by validation with an enzyme\u2010linked immunosorbent assay (\n                      <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were found in levels of S100A8\/A9 in parotid saliva but not whole mouth saliva between patients with\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      compared with healthy and disease control subjects (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.001 and 0.031, respectively). Subgroups of patients with\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      based on lymphoma risk showed significant differences in salivary levels of S100A8\/A9.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The results suggest that salivary levels of S100A8\/A9 can aid in differentiating between\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      , disease control and healthy control subjects, especially the subgroups of\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      with lymphoma or at higher risk of lymphoma.\n                    <\/jats:p>\n                  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Salivary Biology Division Dental Institute King's College London Dental Institute at Guy's Hospital, King's Health Partners London UK"},{"name":"Department of Oral Medicine Guy's and St. Thomas\u2019 National Health Service Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy H.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Mucosal and Salivary Biology Division Dental Institute King's College London Dental Institute at Guy's Hospital, King's Health Partners London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-6927","authenticated-orcid":false,"given":"Stephen J.","family":"Challacombe","sequence":"additional","affiliation":[{"name":"Mucosal and Salivary Biology Division Dental Institute King's College London Dental Institute at Guy's Hospital, King's Health Partners London UK"},{"name":"Department of Oral Medicine Guy's and St. Thomas\u2019 National Health 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