{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T17:02:19Z","timestamp":1763830939533,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470761","81600889"],"award-info":[{"award-number":["81470761","81600889"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Synovial chondromatosis (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) of temporomandibular joint (<jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>) occupies 3% <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> cases. In other joints like hip and knee which were composed hyaline cartilage (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>), loose bodies (<jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s) were reported to be a <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> feature. However, condyle surface and disc in <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content> are fibrous cartilage (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>). Therefore, we proposed a different pathogenesis of <jats:styled-content style=\"fixed-case\">TMJSC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s and synovium were collected from seven <jats:styled-content style=\"fixed-case\">TMJSC<\/jats:styled-content> patients, and histological and immunohistological examinations were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three ways of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> formation were discovered: regular\u2010shaped cartilaginous nodules (<jats:styled-content style=\"fixed-case\">CN<\/jats:styled-content>s) in sublining layer (<jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>) of vascularized synovium, regional chondrification of <jats:styled-content style=\"fixed-case\">SL<\/jats:styled-content>, and finger\u2010like tissue with a tail attaching to synovium. Detached <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s could fuse and were only positively stained by aggrecan. Without synovium attachment to <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s, fused <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s remained a hyaline extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>). However, after synovium attachment, transformation from <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> occurred. Two types of <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> were observed. First type <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> was featured by vertical\u2010distributed type I collagen fibers imbedding few chondrocytes, suggesting mature phase with superior mechanical features. Second type <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> was featured by medium\u2010density chondrocytes with type I collagen and aggrecan\u2010positive <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>, suggesting primary phase. The transformation process started in appearance of 2nd type <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> deriving from synovium covering <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>, and gradually replaced <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> from periphery to center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Three ways of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> formation were closely related. Different with <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> in other joints, hyaline <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s of <jats:styled-content style=\"fixed-case\">TMJSC<\/jats:styled-content> could be replaced by <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> deriving from synovium, during which 2nd type <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content> first replaced <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> and then transformed to 1st type <jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12788","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T09:49:45Z","timestamp":1538819385000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of synovium\u2010derived fibrous cartilage in temporomandibular joint synovial chondromatosis"],"prefix":"10.1111","volume":"48","author":[{"given":"Yingjie","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinyin","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ke","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengxing","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohong","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5794-1117","authenticated-orcid":false,"given":"Xing","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) Key Laboratory of Oral Biomedicine Ministry of Education (KLOBM) School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.04.020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.07.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbo.2014.09.007"},{"key":"e_1_2_7_5_1","first-page":"91","article-title":"A rare case of synovial chondromatosis of the inferior TMJ compartment","volume":"6","author":"Sozzi D","year":"2015","journal-title":"Diagnosis and treatment aspect. 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