{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:28:42Z","timestamp":1785446922050,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    The management of oral submucous fibrosis (\n                    <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content>\n                    ) is quite challenging, and as yet, no effective therapy is available for its management. The present systematic review and meta\u2010analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of\n                    <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content>\n                    . A comprehensive search in PubMed\/Medline, Scopus, and Web of Science databases was conducted to identify the relevant randomized clinical trials. RevMan 5.3 software was used for data analysis. Six randomized controlled trials fulfilled the inclusion criteria. The results of meta\u2010analysis showed statistically significant differences between aloe vera and control groups in alleviating pain\/burning sensation at the end of the first and second month, in favor of aloe vera, but no significant differences were found at the end of the third month. With regard to objective clinical outcomes, no statistically significant differences were found between the groups. Aloe vera has a promising effect in reducing pain\/burning sensation and clinical improvement in patients with\n                    <jats:styled-content style=\"fixed-case\">OSF<\/jats:styled-content>\n                    . However, owing to the marked heterogeneity of the included studies, conducting well\u2010designed trials with long follow\u2010up periods, standardized outcome measures and adequate sample sizes are warranted.\n                  <\/jats:p>","DOI":"10.1111\/jop.12789","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T09:54:36Z","timestamp":1539770076000},"page":"99-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-1377","authenticated-orcid":false,"given":"Sadeq Ali","family":"Al\u2010Maweri","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Science Al\u2010Farabi Colleges Riyadh Saudi 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