{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:59:32Z","timestamp":1776095972792,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Medical Science and Technology Research Fund","award":["A2016207"],"award-info":[{"award-number":["A2016207"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>To investigate alterations in histone modification and histone deacetylases (<jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>s) in patients with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>), and to evaluate correlations with inflammatory cytokine production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Global histone H3\/H4 acetylation and <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content> activity in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells from 23 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 10 healthy control subjects were examined using spectrophotometry. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> levels of eight members of four classes of <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content> genes were measured by real\u2010time quantitative polymerase chain reaction. Forty cytokines involved in inflammation were examined with a cytokine array. The correlation between histone modification and cytokine production was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global histone H3 hypo\u2010acetylation was observed in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients. Patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> had significantly higher <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>s activity,and higher <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>6 and <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>7 m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> level compared with the controls. Of the 40 cytokines in the cytokine array, eight were significantly increased in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients: interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101ra, tumor necrosis factor receptor <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">TNFR II<\/jats:styled-content>), macrophage inflammatory protein 1b (<jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101b), fibrosis\u2010associated tissue inhibitors of metalloproteinase 1 (<jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>)\u20101, monocyte chemotactic protein 1 (<jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101), and eotaxin\u20102. In the <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> group, the acetylation level of histone H3 was negatively correlated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 and <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 production, and the expression of <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>6 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was positively correlated with <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 production. In the non\u2010erosive subgroup, acetylation of histone H3 was negatively correlated with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201016, and <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\u20102 production. In the erosive <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> subgroup, the expression of <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content>7 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was positively correlated with <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101a production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aberrant histone modification of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4+ T cells in peripheral blood could occur in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> patients, and possibly affects inflammatory cytokine production.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12790","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T14:03:46Z","timestamp":1539785026000},"page":"136-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aberrant histone modification and inflammatory cytokine production of peripheral <scp>CD<\/scp>4+ T cells in patients with oral lichen planus"],"prefix":"10.1111","volume":"48","author":[{"given":"Jun","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital Southern Medical University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Stomatological Hospital Southern Medical University Guangzhou Guangdong 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