{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:18:35Z","timestamp":1775225915548,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrence of oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">rOSCC<\/jats:styled-content>) after primary treatment is associated with poor survival outcomes. Salvage treatment with further surgery, radiotherapy and chemotherapy has high morbidity, making patient selection crucial. However, in the recurrence setting, reliable stratification data are scarce. Decision\u2010making in this context is consequently complex. We investigated factors influencing overall survival after <jats:styled-content style=\"fixed-case\">rOSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study of patients with <jats:styled-content style=\"fixed-case\">rOSCC<\/jats:styled-content> (n\u00a0=\u00a083) at the Queen Elizabeth Hospital Birmingham, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> between 2006 and 2016. Associations with overall survival were analysed using univariate and multivariate analyses to identify important clinical prognostic indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival at 1\u00a0year was 32.5% and at 5\u00a0years was 18.1% after a median follow\u2010up of 7.4\u00a0months. Multivariate analysis identified four independent predictors of overall survival following <jats:styled-content style=\"fixed-case\">rOSCC<\/jats:styled-content>: size of primary tumour (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.077; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.034\u20104.172), extent of recurrent disease (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.286; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.545\u20106.991), history of moderate alcohol consumption (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.351; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.162\u20100.763), and close or positive margins at primary resection (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.955; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.063\u20103.595).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified four key factors that help prognostication and risk stratification of <jats:styled-content style=\"fixed-case\">rOSCC<\/jats:styled-content>. Given the high morbidity associated with salvage treatment, we recommend that the multidisciplinary team (<jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>) and the patient weigh these factors carefully when considering further treatment. Further investigation of the biology underlying these oncophenotypes may contribute to better patient stratification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12815","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T21:51:34Z","timestamp":1545429094000},"page":"206-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Factors affecting prognosis in locoregional recurrence of oral squamous cell carcinoma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-2688","authenticated-orcid":false,"given":"Daniele","family":"Borsetto","sequence":"first","affiliation":[{"name":"Institute of Head and Neck Studies and Education Institute of Cancer and Genomic Sciences University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-0588","authenticated-orcid":false,"given":"Gino","family":"Marioni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Otolaryngology Section University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Franchella","sequence":"additional","affiliation":[{"name":"Department of Neuroscience DNS, Otolaryngology Section University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annachiara","family":"Frigo","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health University Hospital of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prav","family":"Praveen","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Department Queen Elizabeth Hospital Birmingham 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