{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:15:45Z","timestamp":1760300145582,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1D1A1A09056771","2018R1A2B6002920"],"award-info":[{"award-number":["2015R1D1A1A09056771","2018R1A2B6002920"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Milan System for Reporting Salivary Gland Cytopathology (Milan System) has previously shown its diagnostic utility by categorizing the seven cytology findings in salivary gland lesions. However, there has been lack of study about the risk of high\u2010grade malignancy in the cytology diagnosis based on the Milan System. Thus, we tried to identify the diagnostic ability of the Milan System for high\u2010grade malignancy and to suggest an improved diagnostic approach for preoperative estimation of high\u2010grade malignancy using the Milan System.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 413 patients with parotid gland tumors, who had undergone surgical resection from 2011 to 2015 were included in the present study retrospectively. Cytopathology was reclassified according to the Milan System by two independent reviewers. The outcomes were risk of malignancy and risk of high\u2010grade malignancy. The diagnostic performance of the Milan System category [Malignant] for detecting high\u2010grade malignancy was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The risk of malignancy was 83.3% and 100% in the Milan System categories [Suspicious for Malignancy] and [Malignant], respectively. Meanwhile, the risk of high\u2010grade malignancy was 16.7% and 55.9% in these two categories. Disease\u2010free survival of patients with high\u2010grade malignancy was significantly worse than those with low\u2010 and intermediate\u2010grade malignancy. Union combining the Milan System category [Malignant] with the presence of nodal metastasis suggested high\u2010grade malignancy with an acceptable diagnostic sensitivity (0.889\u20100.963) and negative predictive value (0.900\u20100.966).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Milan System category [Malignant] with the presence of nodal metastasis suggested parotid gland tumors as high\u2010grade malignancy in a pretreatment setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12816","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T21:52:29Z","timestamp":1545429149000},"page":"222-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Risk of high\u2010grade malignancy in parotid gland tumors as classified by the Milan System for Reporting Salivary Gland Cytopathology"],"prefix":"10.1111","volume":"48","author":[{"given":"Woori","family":"Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsik","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Hae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Young","family":"Hwang","sequence":"additional","affiliation":[{"name":"Statistics and Data Center Research Institute for Future Medicine 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