{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:27:39Z","timestamp":1762867659485,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine which biopsy method produces the best diagnostic yield in patients presenting with autoimmune blistering diseases (<jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>s) of the oral mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective audit of patients who were biopsied at least once for a suspected <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content> of the oral mucosa. The type (incisional or punch) and site of biopsies were recorded in conjunction with case notes, electronic records and histopathological reports in order to calculate sensitivity, specificity and the method of biopsy which produced the superior diagnostic yield.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 125 biopsy samples from 66 patients were identified and reviewed. A diagnosis of <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content> was established in 49 (74%) patients. The chi\u2010square test showed there was a statistically significantly higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0016) diagnostic yield using the punch biopsy technique compared to the scalpel method. The gingiva was the best biopsy site in terms of achieving a definitive diagnosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001) regardless of the biopsy method used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A punch biopsy is more likely than scalpel biopsy to obtain a definitive diagnosis in patients presenting with a suspected oral <jats:styled-content style=\"fixed-case\">AIBD<\/jats:styled-content>. The gingiva is the optimal site to sample.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12817","type":"journal-article","created":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T11:32:46Z","timestamp":1545564766000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["What is the optimal site and biopsy technique for the diagnosis of oral mucosal autoimmune blistering disease?"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-9288","authenticated-orcid":false,"given":"Ciro","family":"Gilvetti","sequence":"first","affiliation":[{"name":"Maxillofacial Unit Queen Victoria Hospital East Grinstead UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Collyer","sequence":"additional","affiliation":[{"name":"Maxillofacial Unit Queen Victoria Hospital East Grinstead UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakshay","family":"Gulati","sequence":"additional","affiliation":[{"name":"Maxillofacial Unit Queen Victoria Hospital East Grinstead UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew William","family":"Barrett","sequence":"additional","affiliation":[{"name":"Department of Histopathology Queen Victoria Hospital East Grinstead UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.151324"},{"key":"e_1_2_7_3_1","first-page":"6","article-title":"Immunofluorescence in oral mucosal diseases \u2013 a review","volume":"2","author":"Sawant P","year":"2014","journal-title":"Oral Surg Oral Med Oral Radiol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2002.119567"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.07.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(95)90010-1"},{"issue":"5","key":"e_1_2_7_7_1","first-page":"E287","article-title":"Sensitivity of direct immunofluorescence in oral diseases. 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