{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:57:26Z","timestamp":1765976246319,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a chronic, inflammatory disease with uncertain etiology. The aim of this study was to assess Interleukin\u201018 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018) gene polymorphism and serum levels in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> cases of Indian origin and to compare them with a control population of similar background.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The assessment of single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 gene at promoter regions \u2212137(G\/C) and \u2212607(C\/A) was done in 70 <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> cases and 70 healthy controls using sequence\u2010specific primer\u2010polymerase chain reaction (<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>). In a subset of this cohort, comprising of 41 <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> cases and 41 controls, serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 levels were assessed using enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean serum levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 among <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> cases were significantly higher when compared to controls. Genotypic and allelic frequencies of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 at position \u2212137(G\/C) showed that <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype and allele G was significantly higher in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> cases, whereas, <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> genotype and C allele was high in the control group. Polymorphism of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 at position \u2212607(C\/A) showed no significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gene polymorphism at \u2212137<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype and allele G seems to be associated with genetic susceptibility to <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> whereas \u2212137<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> and allele C may have a protective role against its development. However, our study lacks clear statistical correlation, the differences observed could be caused by sampling problems and the results could not be fully representative of Indian patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. Further studies are warranted to explore the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 genetic polymorphisms in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12830","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T09:48:47Z","timestamp":1548323327000},"page":"244-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of Interleukin\u201018 gene polymorphism and serum levels in oral lichen planus in an Indian population"],"prefix":"10.1111","volume":"48","author":[{"given":"Deepika","family":"Negi","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Maulana Azad Institute of Dental Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-5805","authenticated-orcid":false,"given":"Aadithya B.","family":"Urs","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Maulana Azad Institute of Dental Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Maulana Azad Institute of Dental Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawna","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Govind Ballabh Pant Institute of Post Graduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Maulana Azad Institute of Dental Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Polipalli","sequence":"additional","affiliation":[{"name":"Pediatrics Research and Genetics Laboratory Department of Pediatrics Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Pediatrics Research and Genetics Laboratory Department of Pediatrics Maulana Azad Medical College  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2007.0056"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2012.0115"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01722.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.007"},{"issue":"11","key":"e_1_2_7_7_1","first-page":"551","article-title":"Role of cytokine gene (interferon\u2010 \u03b3, transforming growth factor\u2010 \u03b21, tumor necrosis factor \u2013\u03b1, interleukin\u20106 and interleukin \u201010) polymorphisms in the risk of oral precancerous lesions in Taiwanese","volume":"30","author":"Hsu HJ","year":"2014","journal-title":"J Med Science"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006314"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12142"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00922.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9327-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00125.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2003.22108.x"},{"issue":"7","key":"e_1_2_7_14_1","first-page":"310","article-title":"Oral lichen planus and lichenoid lesions; 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