{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:11:01Z","timestamp":1784693461757,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Chronic mucosal trauma is suggested as an additional etiologic risk factor for oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>), but there is a lack of experimental\u2010molecular data. If chronic trauma of the oral mucosa is carcinogenic, it should be associated with early genetic alterations seen during typical progression of <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>, like loss of heterozygosity (<jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>). We investigated <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content> in the key chromosomal arms 3p, 9p and 17p in inflammatory fibrous hyperplasia associated with removable dental prosthesis and also in normal oral mucosa, by using the polymorphic microsatellite markers D3S1300 at 3p14.2, D9S1748 at 9p21, D17S1289 at 17p12 and D17S974 at 17p13 and capillary electrophoresis. <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content> was detected in 2\/15 (13%) fibrous hyperplasia samples similarly to other reactive and inflammatory lesions. None of the normal mucosa samples presented <jats:styled-content style=\"fixed-case\">LOH<\/jats:styled-content>. Our experimental\u2010molecular results do not support the hypothesis that trauma associated with dental prosthesis has an important role in oral carcinogenesis.<\/jats:p>","DOI":"10.1111\/jop.12846","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T19:29:16Z","timestamp":1552073356000},"page":"421-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lack of association between denture trauma and loss of heterozygosity confronts the proposed pathologic role of chronic mucosal trauma in oral carcinogenesis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-7434","authenticated-orcid":false,"given":"Vanessa F\u00e1tima","family":"Bernardes","sequence":"first","affiliation":[{"name":"Department of Pathology Biological Sciences Institute Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Gon\u00e7alves","family":"Diniz","sequence":"additional","affiliation":[{"name":"Department of Pathology Biological Sciences Institute Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Carolina","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Chaves","family":"Moraes","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medicine Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-4995","authenticated-orcid":false,"given":"Carolina Cavali\u00e9ri","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pathology Biological Sciences Institute Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-8009","authenticated-orcid":false,"given":"Ricardo Santiago","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais\u2010UFMG Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.203510"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4047\/jap.2015.7.2.129"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2015.09.007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0173"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.11.003"},{"key":"e_1_2_5_7_1","first-page":"323","article-title":"Molecular analysis of oral lichen planus. A premalignant lesion?","volume":"151","author":"Zhang L","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.03.042"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2018.11"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.12846","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:56:58Z","timestamp":1694386618000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,21]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/jop.12846"],"URL":"https:\/\/doi.org\/10.1111\/jop.12846","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,21]]},"assertion":[{"value":"2019-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}