{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:51:49Z","timestamp":1789768309185,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the frequency of oral involvement, there are unexpectedly few studies of either on the oral manifestations of pemphigus or their long\u2010term management, and diagnostic delay in Dentistry is frequent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have examined outcome of patients presenting with predominantly oral pemphigus vulgaris (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>). Ninety\u2010eight subjects were followed up for 85.12\u00a0months and treated with systemic steroids: 48 of them received adjunctive therapy with azathioprine, 16 with rituximab, 13 with mycophenolate mofetil, three with immunoglobulin and one with dapsone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical remission was achieved in 80 patients (84.21%); 39 of them were off therapy and 41 on therapy. Fifteen patients were not in remission, having been under systemic therapy for 72.16\u00a0months. Sixty\u2010nine patients developed detectable adverse effects. Two fatal outcomes were recorded. Each additional year of steroid therapy ensured 47% chance of developing 1 or 2 side effects, and 64% chance of developing more than 3 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s 1.47, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.162\u20101.903; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s 1.64, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.107\u20102.130, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In one of the largest available cohort with the longest follow\u2010up ever reported, we observed that the management remains need\u2010based and patient\u2010specific, still relying on systemic corticosteroids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12847","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T12:37:30Z","timestamp":1552394250000},"page":"406-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term evaluation of pemphigus vulgaris: A retrospective consideration of 98 patients treated in an oral medicine unit in north\u2010west Italy"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-7834","authenticated-orcid":false,"given":"Paolo G.","family":"Arduino","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Gambino","sequence":"additional","affiliation":[{"name":"Dimeas Politecnico of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Sciannameo","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Regional Health Service ASL TO3 Grugliasco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Conrotto","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cabras","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Sciascia","sequence":"additional","affiliation":[{"name":"Center of Research of Immunopathology and Rare Diseases\u2010Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Ricceri","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Regional Health Service ASL TO3 Grugliasco Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Baldovino","sequence":"additional","affiliation":[{"name":"Center of Research of Immunopathology and Rare Diseases\u2010Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley Department of Clinical and Biological Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Carrozzo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Dental Sciences University of Newcastle upon Tyne Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2002.01545.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66829-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01139.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01899.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(95)00459-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13106"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0366-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30241-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02218.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.01.022"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006263.pub2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90080-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90030-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02612.x"},{"key":"e_1_2_7_16_1","first-page":"282","article-title":"Pemphigus vulgaris. A presentation of 14 cases and review of the literature","volume":"10","author":"Camacho\u2010Alonso F","year":"2005","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530050-000000000-00000"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.12.1569"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2002.01544.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00208-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70128-0"},{"key":"e_1_2_7_24_1","first-page":"599","article-title":"Pemphigus vulgaris: a review of treatment over a 19\u2010year period","volume":"16","author":"Ljubojevic S","year":"2002","journal-title":"JEADV"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15658"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12644"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.48.43"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)80066-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12674"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14173"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30070-3"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.12847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:56:32Z","timestamp":1694386592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/jop.12847"],"URL":"https:\/\/doi.org\/10.1111\/jop.12847","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]},"assertion":[{"value":"2019-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}