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The aim of this study was to evaluate the prognostic value of tumor budding for\n                      <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>\n                      patients based on the scoring system recommended by the International Tumor Budding Consensus Conference (\n                      <jats:styled-content style=\"fixed-case\">ITBCC<\/jats:styled-content>\n                      ) 2016.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Tumor budding was scored as\n                      <jats:styled-content style=\"fixed-case\">ITBCC<\/jats:styled-content>\n                      recommended in 255 patients with\n                      <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>\n                      . Then, associations between tumor budding and clinicopathologic parameters were examined. Among them, 136 patients with follow\u2010up data available were used to evaluate overall survival (\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      ) by the Kaplan\u2010Meier method. Prognostic value of tumor budding was assessed by Cox regression analysis. The inter\u2010observer and intra\u2010observer agreement was calculated by the kappa statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tumor budding score was associated with lymph node metastasis, differentiation, invasive pattern, lymphoid infiltrate, tumor relapse, invasive depth, and reduced\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>\n                      patients. The Cox analysis showed high budding score was an independent prognostic factor in patients with all clinical stage and patients with clinical early\u2010stage\n                      <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>\n                      . The high kappa values were achieved in intra\u2010observer and inter\u2010observer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      International Tumor Budding Consensus Conference scoring system is a simple, reliable, and reproducible method to measure tumor budding in\n                      <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>\n                      , which should be included in the routine pathological report.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jop.12856","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T10:28:07Z","timestamp":1553941687000},"page":"451-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Validation of the International 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