{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:09:20Z","timestamp":1773767360292,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["VGHKS105\u2010056, VGHKS106\u2010077, VGHKS107\u2010136 and VGHKS"],"award-info":[{"award-number":["VGHKS105\u2010056, VGHKS106\u2010077, VGHKS107\u2010136 and VGHKS"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Type V collagen (COL<\/jats:styled-content>5), in the functional heterotrimer [\u03b11(V)2<\/jats:sub>\u03b12(V)] isoform, participates in the malignancies of various cancers. However, its role in tongue squamous cell carcinoma (TSCC<\/jats:styled-content>) remains unclear.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>The expression levels of COL<\/jats:styled-content>5A1 and COL<\/jats:styled-content>5A2 polypeptide chains were examined using the tissue microarray from 245 TSCC<\/jats:styled-content> patients with immunohistochemistry. Paired t<\/jats:italic> test and Wilcoxon signed\u2010rank test were performed for comparisons among the groups. Survival rates were estimated by using the Kaplan\u2010Meier method and compared with log\u2010rank tests. A Cox proportional hazards model was used to evaluate the impact of protein expression level on survival rate.<\/jats:p><\/jats:sec>Results<\/jats:title>Expression level of COL<\/jats:styled-content>5A1 was significantly increased in tumor tissues (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) compared to that in corresponding adjacent normal tissues. High expression level of COL<\/jats:styled-content>5A1 was associated with advanced pathological stage (III<\/jats:styled-content>, IV<\/jats:styled-content>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.015) and lymph node metastasis (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.005) of TSCC<\/jats:styled-content> patients. High expression level of COL<\/jats:styled-content>5A1 was also correlated with poor disease\u2010specific survival (DSS<\/jats:styled-content>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.001) and disease\u2010free survival (DFS<\/jats:styled-content>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003) in TSCC<\/jats:styled-content> patients. However, high expression level of COL<\/jats:styled-content>5A2 was correlated with better DFS<\/jats:styled-content> in TSCC<\/jats:styled-content> patients (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.043). Moreover, co\u2010expression level of high (COL<\/jats:styled-content>5A1)2<\/jats:sub>\/low (COL<\/jats:styled-content>5A2) heterotrimer was correlated with worse DSS<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.004) and DFS<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.004).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>COL<\/jats:styled-content>5A1 is an unfavorable factor for tumorigenesis, clinicopathological outcomes, and prognosis, whereas COL<\/jats:styled-content>5A2 is only a favorable factor for prognosis in TSCC<\/jats:styled-content>. The co\u2010expression of high (COL<\/jats:styled-content>5A1)2\/low (COL<\/jats:styled-content>5A2) heterotrimer is a more potential unfavorable factor for prognosis in TSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12861","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:34:09Z","timestamp":1555029249000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Differential clinical significance of COL<\/scp>5A1 and COL<\/scp>5A2 in tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"48","author":[{"given":"Hung\u2010Chih","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Oral & Maxillary Surgery Department of Stomatology Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Dental Laboratory Technology Shu Zen College of Medicine and Management Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Kai","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Show Chwan Memorial Hospital Changhua Taiwan"},{"name":"Department of Orthopedics National Cheng Kung University Hospital Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Wen","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Medicine for International Students I\u2010Shou University Kaohsiung Taiwan"},{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u2010Jung","family":"Weng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"},{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huei\u2010Han","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Ming","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010Chien","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Ching","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pi\u2010Chuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Service Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yow\u2010Ling","family":"Shiue","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Ying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Wang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"},{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Department of Chemical Biology National Pingtung University of Education Pingtung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luo\u2010Ping","family":"Ger","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"},{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7849-8940","authenticated-orcid":false,"given":"Pei\u2010Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Department of Oral Hygiene Shu\u2010Zen Junior College of Medicine and Management Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12813"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.023820"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.091363"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005087"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178581"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.17648"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0912"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2008.06.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/bc.2011.056"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.10.020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026712"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.15371"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.6.875"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.09.025"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1256"},{"issue":"2","key":"e_1_2_6_18_1","first-page":"239","article-title":"Discovery of signature genes in gastric cancer associated with prognosis","volume":"63","author":"Zhao X","year":"2016","journal-title":"Neoplasma"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.08.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.04.066"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3945"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.468"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2123-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn123"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161007"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.9.4607"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1826-2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.06.003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3929"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2546"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787846757"}],"container-title":["Journal of Oral Pathology & Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jop.12861","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T02:03:34Z","timestamp":1694311414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,29]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/jop.12861"],"URL":"https:\/\/doi.org\/10.1111\/jop.12861","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,29]]},"assertion":[{"value":"2019-02-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}