{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:11:50Z","timestamp":1784675510420,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus vulgaris (PV) is an autoimmune blistering disease driven by pathogenic antibodies to desmoglein\u20101 and \u20103, levels of which correlate with disease activity. Anti\u2010desmoglein\u20103 IgG4 isotype antibodies are said to predominate in active disease and anti\u2010desmoglein\u20103 IgG1 in remission; however, these observations arose from vertical studies, with limited assessments of clinical activity. The objective of this study was to examine the relationship between desmoglein autoantibodies, subdivided by isotype and disease activity using the validated PV activity tool \u201cPemphigus Disease Area Index (PDAI).\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty PV patients with predominantly mucosal disease were studied prospectively, 24 serially, and PDAI and anti\u2010desmoglein antibodies recorded at each visit over a period of up to 15\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At enrolment, only anti\u2010desmoglein\u20103 IgG4 levels were significantly associated with disease activity but the correlation was weak. During follow\u2010up, within\u2010patient changes in disease activity correlated with changes in anti\u2010desmoglein\u20103 IgG levels, but correlations were similar for both anti\u2010desmoglein\u20103 IgG1 and IgG4. These trends were not observed in anti\u2010desmoglein\u20101 IgG levels, although the majority of patients were negative at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010desmoglein\u20103 IgG4 levels correlated only weakly with PDAI scores at a single time point. Reciprocity of IgG1 vs IgG4 anti\u2010desmoglein\u20103 with changes in disease activity over time could not be confirmed, but rather, changes in levels of anti\u2010desmoglein\u20103 IgG, irrespective of isotype, were useful in following individual patient responses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12913","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T09:15:41Z","timestamp":1560417341000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pemphigus vulgaris disease activity: The role of antibodies to desmogleins and their isotype"],"prefix":"10.1111","volume":"48","author":[{"given":"Sue\u2010Ching","family":"Yeoh","sequence":"first","affiliation":[{"name":"Sydney Oral Medicine Sydney New South Wales Australia"},{"name":"Department of Clinical Immunology and Allergy Royal Prince Alfred Hospital Sydney New South Wales Australia"},{"name":"Chris 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