{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:21:39Z","timestamp":1790835699984,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sigrid Juselius Foundation"},{"DOI":"10.13039\/501100005634","name":"The Finnish Dental Society Apollonia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Plandent Oy and Planmeca Oy"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral lichen planus (OLP) is a chronic T\u2010cell\u2010mediated inflammatory disease, which is associated with increased risk of developing oral squamous cell carcinoma. Epithelial\u2010to\u2010mesenchymal transition is a physiological phenomenon occurring during growth and organogenesis, but it has also an important role in tumorigenesis. In the present work, we studied the expression of known epithelial\u2010to\u2010mesenchymal transition markers in oral lichen planus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 54 oral lichen planus and 22 control samples were analyzed for epithelial\u2010to\u2010mesenchymal transition markers. Samples were immunohistochemically stained for claudin\u20101, claudin\u20104 and claudin\u20107, cadherin\u20101 (E\u2010cadherin), Twist\u2010related protein 1 (TWIST1) and zinc finger E\u2010box\u2010binding homeobox 1 (ZEB1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression of claudin\u20101, claudin\u20104 and E\u2010cadherin was significantly weaker in oral lichen planus epithelium compared to controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The quantity of claudin\u20107\u2010expressing cells (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and claudin\u20107 staining intensity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in the stroma was greater in lichen planus than in control samples. TWIST1 and ZEB1 stainings were negative in the epithelium in both lichen planus and controls. The number of TWIST1\u2010expressing cells in the stroma was higher in lichen planus than in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). There was a statistically significant difference in ZEB1 staining intensity in the stroma between lichen planus and control samples (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data indicate that the expression of claudin\u20101, claudin\u20104 and E\u2010cadherin is decreased in oral lichen planus. This may lead to disturbance in epithelial tight junctions, cell\u2010cell connections and epithelial permeability, contributing to oral lichen planus pathogenesis. Based on the present study, the role of TWIST1 and ZEB1 in oral lichen planus remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12917","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T12:21:03Z","timestamp":1561206063000},"page":"735-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Alterations in the expression of EMT\u2010related proteins claudin\u20101, claudin\u20104 and claudin\u20107, E\u2010cadherin, TWIST1 and ZEB1 in oral lichen planus"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-1150","authenticated-orcid":false,"given":"Lasse","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"first","affiliation":[{"name":"Institute of Biomedicine, School of Medicine, Faculty of Health Sciences University of Eastern Finland Kuopio 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