{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:34:02Z","timestamp":1785008042210,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lichenoid granulomatous reaction can be subcategorized into lichenoid granulomatous dermatitis or lichenoid granulomatous stomatitis. It is described in the literature as demonstrating a band\u2010like lichenoid infiltration with clusters of histiocytic or granuloma formation. In this study, we presented a large case series of lichenoid granulomatous stomatitis including demographics, histological features, and subcategories and compared findings with current literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and materials<\/jats:title><jats:p>We retrieved all cases diagnosed with lichenoid reaction with granulomatous inflammation between January 1, 2000, and August 1, 2016, from the University of Florida Oral Pathology Biopsy Service Archives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47 patients with tissue from 50 biopsy sites were included. The majority of the cases were noted in females (64%) with a mean age of 59\u00a0years (range 30\u201088). Most patients were Caucasian, and the most common sites in descending order were: gingiva, buccal mucosa, vestibule, tongue, lip, palate, and occasional multifocal involvement. Clinical impressions by the treating clinicians included leukoplakia, dysplasia, carcinoma in situ, squamous cell carcinoma, lichen planus, vesiculobullous disease, trauma, and allergy. The histologic features of these cases ranged from lichenoid mucositis with numerous aggregates of histiocytes to well\u2010formed granulomas, in accordance with previous classifications of similar dermatologic lesions. All cases revealed positive CD 68 in the histiocytic infiltrates and were negative for microorganisms utilizing acid\u2010fast bacilli, Grocott methenamine\u2010silver, and periodic acid\u2010Schiff stains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lichenoid granulomatous disease may be more common than previously reported; however, its etiology remains unknown and patients should be kept under long\u2010term clinical follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12918","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T12:20:02Z","timestamp":1561206002000},"page":"846-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lichenoid reaction with granulomatous stomatitis: A retrospective histologic study of 47 patients"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-0573","authenticated-orcid":false,"given":"Abdulaziz","family":"Hakeem","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida College of Dentistry Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indraneel","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida College of Dentistry Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Aljabri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida College of Dentistry Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Bindakhil","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida College of Dentistry Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krunal","family":"Pachigar","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida College of Dentistry Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-8480","authenticated-orcid":false,"given":"Mohammed N.","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida College of Dentistry Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald 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