{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:58:35Z","timestamp":1768521515760,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T00:00:00Z","timestamp":1569715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acinar progenitor cells within salivary glands have decreased regenerative capacity and exhibit shorter telomeres in primary Sj\u00f6gren's syndrome (pSS) patients. We investigated whether DNA of saliva, PBMCs, and labial salivary gland (LSG) biopsy tissue have shorter telomeres in pSS compared to controls. mRNA expression of genes associated with pSS pathogenesis (ETS1, LEF1, and MMP9), telomere DNA damage response (ATM), senescence (CDKN2A), telomerase inhibition (IFN\u2010y, TGF\u03b21), and the shelterin complex (TPP1, POT1) were assessed in LSG tissue by qRT\u2010PCR to examine potential defects in telomere maintenance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relative telomere length in DNA of saliva, PBMCs, and LSGs from non\u2010pSS sicca and pSS patients was measured using qPCR. Saliva DNA telomere length was further compared to healthy controls. Expression of genes affecting telomere maintenance was analyzed in LSGs using qRT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary Sj\u00f6gren's syndrome patients have shorter telomeres in saliva DNA (n\u00a0=\u00a021) than healthy controls (n\u00a0=\u00a027) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0035). ATM mRNA expression was higher in pSS LSG tissue (n\u00a0=\u00a016) vs non\u2010pSS sicca patients (n\u00a0=\u00a013) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0283) and strongly correlated with LEF1, TPP1, and POT1 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01, r\u00a0&gt;\u00a00.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with pSS exhibited significant telomere erosion in saliva DNA. Overexpression of ATM in LSGs could represent a compensatory response to telomere shortening. The role of LEF1 in telomere erosion remains to be elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12961","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T14:53:46Z","timestamp":1568732026000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Telomere erosion in Sj\u00f6gren's syndrome: A multi\u2010tissue comparative analysis"],"prefix":"10.1111","volume":"49","author":[{"given":"Braxton","family":"Noll","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Carolinas Medical Center \u2010 Atrium Health Charlotte NC USA"},{"name":"Department of Biological Sciences University of North Carolina at Charlotte Charlotte NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Bahrani Mougeot","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Carolinas Medical Center \u2010 Atrium Health Charlotte NC USA"},{"name":"Department of Biological Sciences University of North Carolina at Charlotte Charlotte NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Carolinas Medical Center \u2010 Atrium Health Charlotte NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-1769","authenticated-orcid":false,"given":"Jean\u2010Luc C.","family":"Mougeot","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Carolinas Medical Center \u2010 Atrium Health Charlotte NC USA"},{"name":"Department of Biological Sciences University of North Carolina at Charlotte Charlotte NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,29]]},"reference":[{"issue":"20","key":"e_1_2_9_2_1","first-page":"354","article-title":"The diagnosis and 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