{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:37:43Z","timestamp":1778283463224,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T00:00:00Z","timestamp":1574553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","award":["FIR2017"],"award-info":[{"award-number":["FIR2017"]}],"id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Craniofacial morphogenesis is the result of an intricate multistep network of tightly controlled spatial and temporal signalling that involves several molecules and transcription factors organized into highly coordinated pathways. Any alteration in even one step of this delicate process can lead to congenital malformations such as cleft palate. One of the first steps in embryonal orofacial development is the migration of cells from the neural crests to the branchial arches. Next, the cells have to proliferate, differentiate, move and connect to each other in order to correctly form the palate. Cell contraction, promoted by the interaction of non\u2010muscle myosin II and actin A, is a crucial step in morphogenesis and is regulated by ROCK1 protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A family\u2010based association study was carried out in order to verify whether or not genetic variants of <jats:italic>ROCK1<\/jats:italic> were associated with non\u2010syndromic cleft palate (nsCP). Two cohorts from Italy and Iran, a total of 189 nsCP cases and their parents were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rs35996865\u2010G allele was under\u2010transmitted in cases of nsCP [<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006, odds ratio (OR)\u2009=\u20090.63 (95% CI 0.45\u20100.88)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This investigation reveals for the first time data supporting a role for <jats:italic>ROCK1<\/jats:italic> in nsCP aetiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12973","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:28:37Z","timestamp":1573604917000},"page":"164-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>ROCK1<\/i> is associated with non\u2010syndromic cleft palate"],"prefix":"10.1111","volume":"49","author":[{"given":"Annalisa","family":"Palmieri","sequence":"first","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-9910","authenticated-orcid":false,"given":"Luca","family":"Scapoli","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Carrozzo","sequence":"additional","affiliation":[{"name":"School of Dental Sciences University of Newcastle upon Tyne Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cura","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine University of Ferrara Ferrara 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