{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:00Z","timestamp":1747186620096,"version":"3.40.5"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The systemic use of corticosteroid is the treatment of choice for patients with pemphigus vulgaris (PV), but adverse effects are frequent. To date, the use of rituximab (RTX) for PV patients is usually indicated when they failed first\u2010line immunosuppressive therapies. The early use of RTX could theoretically lessen adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center study on patients with predominantly oral PV, treated with systemic corticosteroid and the prompt use of 1000\u00a0mg of intravenous RTX two weeks apart. We evaluated the clinical response and the reported adverse effect during a period of 24\u00a0months, comparing those with a previously published series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group comprised 11 patients, while the control group comprised 98 patients. The average time to achieve complete clinical remission was 3.2\u00a0\u00b1\u00a02.72\u00a0months. Study group took steroids for a mean time of 11.09\u00a0\u00b1\u00a02.02\u00a0months, and they are all actually disease\u2010free with no medication. Only three patients (27.3%) developed plain side effects. The effect of the length of the corticosteroid therapy on the side effects (also adjusted by sex, age, and clinical oral involvement) was statistically different in the two groups: the prompt use of RTX reduced of 94% the chance to have adverse effects (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report of the use of RTX as first line of therapy for PV patients with predominantly oral involvement. With the proposed regimen, the adverse effects have been minimized compared with classic systemic corticosteroid\u2010centered therapy. Multi\u2010center randomized controlled trail is however necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12982","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T14:02:56Z","timestamp":1575554576000},"page":"177-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The prompt use of rituximab could decrease adverse effects in patient with pemphigus vulgaris: A preliminary evaluation"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8798-7834","authenticated-orcid":false,"given":"Paolo G.","family":"Arduino","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Carbone","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-0695","authenticated-orcid":false,"given":"Davide","family":"Conrotto","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Sciannameo","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology Regional Health Service ASL TO3 Grugliasco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Gambino","sequence":"additional","affiliation":[{"name":"Dimeas Politecnico of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cabras","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR\u2010Dental School University of Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Carrozzo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Dental Sciences University of Newcastle upon Tyne Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Baldovino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences Center of Research of Immunopathology and Rare Diseases\u2010Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12847"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12674"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.01.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01899.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30070-3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12951"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12948"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.18.06073-X"}],"container-title":["Journal of Oral Pathology &amp; 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