{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:21:28Z","timestamp":1787869288957,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T00:00:00Z","timestamp":1586044800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ80055"],"award-info":[{"award-number":["2019JJ80055"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ80054"],"award-info":[{"award-number":["2019JJ80054"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010451","name":"Health and Family Planning Commission of Hunan Province","doi-asserted-by":"publisher","award":["No. B2019133"],"award-info":[{"award-number":["No. B2019133"]}],"id":[{"id":"10.13039\/501100010451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This meta\u2010analysis was performed to systematically evaluate the efficacy of hyaluronidase combined with corticosteroids compared with other drugs in improving maximum mouth opening and alleviating the burning sensation in patients with oral submucous fibrosis (OSF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Embase, Web of Science and the Cochrane Library were searched. RevMan 5.3 software was used for the meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies involving 244 patients with OSF were analysed. No significant difference in improvement of maximum mouth opening was found between the hyaluronidase and control groups (lycopene, pentoxifylline, aloe vera, dexamethasone, Turmix [curcumin\u00a0+\u00a0piperine] and isoxsuprine) at 1\u00a0month (mean difference [MD]: 0.32, 95% confidence interval [CI]: \u22120.92\u20101.56, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.61, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a057%), 2\u00a0months (MD: 0.49, 95% CI: \u22120.14\u20101.12, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.12, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a041%) or 3\u00a0months (MD: 0.40, 95% CI: \u22121.08\u20101.87, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.60, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a092%). Additionally, no statistically significant difference was found in alleviation of the burning sensation between the two groups at 1\u00a0month (MD: 0.54, 95% CI: \u22120.62\u20101.71, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.36, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%), 2\u00a0months (MD: 0.53, 95% CI: \u22120.85\u20101.91, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.45, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%) or 3\u00a0months (MD: 0.64, 95% CI: \u22121.07 to 2.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.46, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to this meta\u2010analysis, weak evidence indicates that hyaluronidase combined with corticosteroids has no additional clinical benefit over control drugs (lycopene, pentoxifylline, aloe vera, dexamethasone, Turmix and isoxsuprine) in improving maximum mouth opening and alleviating the burning sensation in patients with OSF. Therefore, more high\u2010quality, multi\u2010centre randomized controlled trials with larger samples are needed to further assess the efficacy of hyaluronidase combined with corticosteroids in the treatment of OSF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13009","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T21:19:20Z","timestamp":1583615960000},"page":"311-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of hyaluronidase combined with corticosteroids in treatment of oral submucous fibrosis: A meta\u2010analysis of randomized controlled clinical trials"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-0505","authenticated-orcid":false,"given":"Jincai","family":"Guo","sequence":"first","affiliation":[{"name":"Changsha Stomatological Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xie","sequence":"additional","affiliation":[{"name":"Changsha Stomatological Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Mao","sequence":"additional","affiliation":[{"name":"Graduate School of Hunan University of Traditional Chinese Medicine Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mining","family":"Liang","sequence":"additional","affiliation":[{"name":"Clinical Nursing Teaching and Research Section The Second Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"Changsha Stomatological Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12277"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12726"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.04.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600727"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2786"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2010.0194"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.08.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300404.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.11.021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.12.056"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016339"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100096286"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(88)90043-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.07.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0824-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_1192_16"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-2527"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2014.11.003"},{"key":"e_1_2_9_20_1","first-page":"171","article-title":"Submucous fibrosis of the palate in diet\u2010preconditioned Wistar rats. 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