{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:42:09Z","timestamp":1761864129005,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:00:00Z","timestamp":1592006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Synovitis is characterized by the infiltration of inflammatory cells and often accompanies the pathological progression of the clinical symptoms affecting the temporomandibular joint (TMJ), such as pain, snapping, and limited mouth opening. It has been suggested that the signal transduction pathway and resultant proinflammatory mediators play important roles in the pathogenesis of synovitis. Therefore, in this present research, we aimed to investigate the changes in the expressions of stromal cell\u2010derived factor 1 (SDF\u20101) and interleukin (IL)\u20101\u03b2 in rats with occlusal interference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We divided 36 male Wistar rats into the following groups: Group A (control group), Group B (occlusal interference group), and Group C (AMD3100 group). Synovial inflammation was induced in the rats in Groups B and C to establish the occlusal interference model. The inflammatory changes were detected, and the expressions of SDF\u20101 and IL\u20101\u03b2 in the synovium were assayed via immunostaining and a real\u2010time quantitative polymerase chain reaction (PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Group B, obvious inflammatory changes were observed in the synovial membranes; additionally, the SDF\u20101 and IL\u20101\u03b2 expression levels were significantly higher at the protein and mRNA levels. However, in Group C, these experimental results were inhibited by an injection with AMD3100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results may indicate that SDF\u20101 regulates the expression level of inflammatory factors, such as IL\u20101\u03b2, in the synovial membranes of rats with occlusal interference. Our findings suggest that the SDF\u20101 axis may contribute to the onset of synovitis during the development of TMJ joint disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13040","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:56:34Z","timestamp":1590407794000},"page":"933-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Stromal cell\u2010derived factor\u20101 regulates the secretion of interleukin\u20101\u03b2 in the temporomandibular joint of rats with synovial inflammation"],"prefix":"10.1111","volume":"49","author":[{"given":"Dong","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Prosthodontics Shandong Key Laboratory of Oral Tissue Regeneration &amp; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Shandong University Stomatology Hospital  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Jinan Stomatological Hospital  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Jinan Stomatological Hospital  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Jinan Stomatological Hospital  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Jinan Stomatological Hospital  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Shandong Key Laboratory of Oral Tissue Regeneration &amp; 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