{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:18:16Z","timestamp":1762607896363,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune mucocutaneous blistering diseases (AMBDs) represent a heterogeneous group of organ\u2010specific and potentially life\u2010threatening diseases. We sought to determine the relationship between clinical remission and therapeutic regimens with clinical type and phenotype of AMBDs, as well as clinical outcomes achieved based on different therapeutic regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single\u2010center study on 169 AMBDs patients, including pemphigus vulgaris (PV), mucous membrane pemphigoid (MMP), paraneoplastic autoimmune multiorgan syndrome (PAMS), and lichen planus pemphigoides (LPP), was performed from 1994 to 2019 in an oral medicine tertiary center, where we collected sociodemographic data, clinical type and phenotype, prescribed therapies, and related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of AMBDs patients was 55.0\u00a0\u00b1\u00a016.4\u00a0years. They were followed for a mean of 8.4\u00a0\u00b1\u00a05.8\u00a0years. The majority of these patients (62.1%) were successfully managed with conventional immunosuppressive therapy (CIST) alone. However, 37.9% of patients required additional biological treatments, either because they were non\u2010responders or developed severe side effects from CIST, or because of the rapid and severe progression of the disease. Overall, complete clinical remission was achieved in 92.3% of patients. A statistically significant difference was noted between the frequency distribution of AMBDs patients among different therapeutic regimens (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.002), of different clinical phenotype and type of AMBDs patients and clinical remission (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.012 and <jats:italic>P\u00a0<\/jats:italic>=\u00a0.005, respectively). No difference was reported regarding clinical outcomes and different therapeutic regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AMBDs' management may be challenging, nonetheless CIST and biologic regimens introduced, when needed as reliable alternatives to CIST, result in a very high percentage of CCR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13059","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T22:12:54Z","timestamp":1591999974000},"page":"672-680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Autoimmune mucocutaneous blistering diseases in the south of Italy: a 25\u2010year retrospective study on 169 patients"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-5650","authenticated-orcid":false,"given":"Elena","family":"Calabria","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry Federico II University of Naples  Naples Italy"},{"name":"UCL Eastman Dental Institute  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-3523","authenticated-orcid":false,"given":"Giulio","family":"Fortuna","sequence":"additional","affiliation":[{"name":"Glasgow Dental School &amp; Hospital School of Medicine, Dentistry and Nursing College of Medical, Veterinary and Life Sciences University of Glasgow  Glasgow UK"},{"name":"D.eb.RA. Mexico Foundation  Nuevo Leon Mexico"},{"name":"Federico Navarro Institute\u2013School of Orgonomy \u201cPiero Borrelli\u201d  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Aria","sequence":"additional","affiliation":[{"name":"Department of Economics and Statistics Federico II University of Naples  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele D.","family":"Mignogna","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive Sciences and Dentistry Federico II University of Naples  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8662-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8633-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600972099"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-018-8986-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.11.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.12.002"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Updates on the management of autoimmune blistering diseases","volume":"19","author":"Hooten JN","year":"2014","journal-title":"Skin Ther Lett"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.12.044"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062930"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.09.049"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02151.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02809.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03610.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02292.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S97214"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04801.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12847"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-016-0343-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530050-000000000-00000"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12041"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.183992"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12644"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.029"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14143"},{"key":"e_1_2_8_30_1","first-page":"e13016","article-title":"Iranian guideline for rituximab therapy in pemphigus patients","author":"Daneshpazhooh M","year":"2019","journal-title":"Dermatol Ther"},{"issue":"67","key":"e_1_2_8_31_1","first-page":"370","article-title":"EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection","volume":"2017","author":"European Association for the Study of the Liver. 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