{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:07:23Z","timestamp":1771852043977,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE024629"],"award-info":[{"award-number":["DE024629"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk factors neck muscle tension, prolonged jaw opening, and female gender are associated with developing temporomandibular disorders (TMD), which are characterized by persistent sensitization of trigeminal neurons and enhanced pain signaling. Dietary supplementation with a grape seed extract (GSE) can modulate expression of proteins that decrease neuronal excitability and trigeminal sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mechanical nocifensive thresholds over the masseter were determined using von Frey filaments in male and female adult Sprague Dawley rats. To promote trigeminal sensitization, animals were injected with complete Freund\u2019s adjuvant in the upper trapezius. After 8\u00a0days, animals were subjected to near maximal jaw opening and head withdrawal responses were determined for 28\u00a0days. Some animals received continuous supplementation with 0.5% GSE in their drinking water two weeks prior to trapezius injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prolonged jaw opening increased the average number of nocifensive responses to mechanical stimuli for 14\u00a0days in males and females. However, trapezius inflammation prior to jaw opening promoted persistent mechanical sensitivity up to 28\u00a0days post\u2010jaw opening in females, while in males nociceptive levels were still elevated at day 21. Supplementation with GSE, which is enriched in polyphenols and exhibits antioxidant and COX\u20102 activity, inhibited trigeminal nociception in response to jaw opening in both male and female sensitized animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings provide evidence that multiple risk factors contribute to the development of a prolonged state of trigeminal sensitization that is more severe in females and provide preclinical evidence that supplementation with GSE could be beneficial in the management of TMD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.13066","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T22:15:18Z","timestamp":1592000118000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dietary supplementation with grape seed extract prevents development of trigeminal sensitization and inhibits pain signaling in a preclinical chronic temporomandibular disorder model"],"prefix":"10.1111","volume":"49","author":[{"given":"Lauren E.","family":"Cornelison","sequence":"first","affiliation":[{"name":"Missouri State University Springfield Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelima","family":"Chelliboina","sequence":"additional","affiliation":[{"name":"Missouri State University Springfield Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara E.","family":"Woodman","sequence":"additional","affiliation":[{"name":"Missouri State University Springfield Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-6156","authenticated-orcid":false,"given":"Paul L.","family":"Durham","sequence":"additional","affiliation":[{"name":"Missouri State University Springfield Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.09.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/2176-9451.20.1.127-133.sar"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.08.006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.52901"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00068-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00028-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-5-75"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385198-7.00007-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1557"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.4474"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00194-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-002-0040-y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01348-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05608.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02074.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/np068054v"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365116"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-91"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2015-0026"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.240"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2011.43.10.062"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5104"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000628"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/512792"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328136c1f9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2004.03.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-009-0050-9"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-79090-7_13"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12725"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.02.004"}],"container-title":["Journal of Oral Pathology &amp; 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